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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 256 - 261 (6page)
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초록· 키워드
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Objective Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may play an important role in the ethiopathogenesis of ADHD. In this study, we aimed to investigate whether serum galectin-3 levels are related to ADHD in childhood. Methods The current study consisted of 35 treatment-naive children with ADHD and 35 control subjects. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were determined by the self-report scale. Venous blood samples were collected and serum galectin-3 levels were measured. Results The ADHD group had significantly higher serum Galectin-3 levels than the control group. To control confounding factors, including age, sex, and BMI percentile, one-way analysis of covariance (ANCOVA) test was also performed. Analyses revealed a significantly higher serum log- Galectin-3 levels in children with ADHD compared to controls. No association was found between the mean serum galectin-3 levels and sociodemographic characteristics and clinical test scores, except the oppositional defiant behavior scores. Conclusion Our research supports the hypothesis that serum levels of galectin-3 might be related to ADHD.
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참고문헌 (36)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition / American Psychiatric Association
Willcutt EG / 2012 / The prevalence of DSM-IV attention-deficit/hyperactivity disorder : a meta-analytic review / Neurotherapeutics 9:490~499
Thomas R / 2015 / Prevalence of attention-deficit/hyperactivity disorder : a systematic review and metaanalysis / Pediatrics 135:e994~e1001
Ercan ES / 2019 / The prevalence of childhood psychopathology in Turkey : a cross-sectional multicenter nationwide study(EPICPAT-T) / Nord J Psychiatry 73:132~140
Thapar A / 2013 / Practitioner review: What have we learnt about the causes of ADHD? / J Child Psychol Psychiatry 54:3~16
Willcutt EG / 2012 / The prevalence of DSM-IV attention-deficit/hyperactivity disorder : a meta-analytic review / Neurotherapeutics 9:490~499
Thomas R / 2015 / Prevalence of attention-deficit/hyperactivity disorder : a systematic review and metaanalysis / Pediatrics 135:e994~e1001
Ercan ES / 2019 / The prevalence of childhood psychopathology in Turkey : a cross-sectional multicenter nationwide study(EPICPAT-T) / Nord J Psychiatry 73:132~140
Thapar A / 2013 / Practitioner review: What have we learnt about the causes of ADHD? / J Child Psychol Psychiatry 54:3~16
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