지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: This study investigated the effects of Hansu-Daebowon (HDW) on bone resorption in vitro and bone loss in vivo. Methods: Osteoclast differentiation was measured by counting TRAP (+) MNC formed from RAW 264.7 in the presence of RANKL. Bone pit formation was determined in an artificial bone slice loaded with RANKL-stimulated osteoclasts. To elucidate the mechanisms of the inhibitory effects of HDW on bone resorption and osteoclast differentiation, osteoclastogenic genes (i.e. TRAP, MMP-9, NFATc1, c-Fos, and Cathepsin K) were measured using real time PCR. Furthermore, bone loss was observed using micro-CT in an LPS-treated mammal model. Results: HDW inhibited the bone pit formation in vitro and inhibited bone loss in vivo. Moreover, HDW decreased the number of TRAP (+) MNCs in the presence of RANKL, and HDW inhibited the expressions of cathepsin K, MMP-9, TRAP, NFATc1, and c-Fos in the osteoclasts. Conclusion: HDW exerts inhibitory effects on bone loss and bone resorption resulting from the inhibitions of osteoclast differentiation and osteoclastogenic gene expression.
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참고문헌 (19)
참고문헌 신청
McBride JA / 2016 / Testosterone deficiency in the aging male / Ther Adv Urol 8(1):47~60
Kling JM / 2014 / Osteoporosis prevention, screening, and treatment : a review / J Womens Health 23(7):563~572
Sweet MG / 2009 / Diagnosis and treatment of osteoporosis / Am Fam Physician 79(3):193~200
Tanaka S / 2007 / Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/ RANK/OPG system / Am J Nephrol 27(5):466~478
Noguchi T / 2018 / Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway / Biochem Biophys Res Commun 503(2):644~650
Kling JM / 2014 / Osteoporosis prevention, screening, and treatment : a review / J Womens Health 23(7):563~572
Sweet MG / 2009 / Diagnosis and treatment of osteoporosis / Am Fam Physician 79(3):193~200
Tanaka S / 2007 / Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/ RANK/OPG system / Am J Nephrol 27(5):466~478
Noguchi T / 2018 / Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway / Biochem Biophys Res Commun 503(2):644~650
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