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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 261 - 269 (9page)
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초록· 키워드
오류제보하기
Allergic march is a part of a phase that occurs in a series of continuous steps in disease of pediatricpatients, which proceeds from atopic dermatitis to asthma, and from asthma to allergic rhinitis. Recently, several hypotheses have been raised to explain the allergic march. Among them,the study of the hygiene theory related to microbiota, and the study on the role of innate cytokineswhich occurs in skin barrier damage are attracting attentions. If the interaction betweenthe microbiota and the immune system occurs improperly, the activity of the regulatory T cellbecomes insufficient and the immune-regulatory function is reduced, resulting in allergic diseases. Because of the skin barrier disruption, the innate cytokines are activated, thus resultingin Th2 inflammation reaction being increased. Considering this pathogenesis, blocking thelinkage to pathogens is regarded to play an important role in preventing and treating allergicmarch.
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등록된 정보가 없습니다.
참고문헌 (66)
참고문헌 신청
Strachan DP / 1989 / Hay fever, hygiene, and household size / BMJ 299(6710):1259~1260
Lynch SV / 2014 / Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children / J Allergy Clin Immunol 134(3):593~601 e12
Thorne PS / 2005 / Endotoxin exposure is a risk factor for asthma : the national survey of endotoxin in United States housing / Am J Respir Crit Care Med 172(11):1371~1377
Braun-Fahrländer C / 2002 / Environmental exposure to endotoxin and its relation to asthma in school-age children / N Engl J Med 347(12):869~877
Strachan DP / 2015 / Siblings, asthma, rhinoconjunctivitis and eczema : a worldwide perspective from the International Study of Asthma and Allergies in Childhood / Clin Exp Allergy 45(1):126~136
Lynch SV / 2014 / Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children / J Allergy Clin Immunol 134(3):593~601 e12
Thorne PS / 2005 / Endotoxin exposure is a risk factor for asthma : the national survey of endotoxin in United States housing / Am J Respir Crit Care Med 172(11):1371~1377
Braun-Fahrländer C / 2002 / Environmental exposure to endotoxin and its relation to asthma in school-age children / N Engl J Med 347(12):869~877
Strachan DP / 2015 / Siblings, asthma, rhinoconjunctivitis and eczema : a worldwide perspective from the International Study of Asthma and Allergies in Childhood / Clin Exp Allergy 45(1):126~136
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