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논문 기본 정보

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학술저널
저자정보
Samra Mona Salem (Department of Pediatrics Inha University College of Medicine Incheon Korea.) 임대현 (Department of Pediatrics Inha University College of Medicine Incheon Korea.) Han Man Yong (Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Kore) 지혜미 (Department of Pediatrics CHA Bundang Medical Center CHA University School of Medicine Seongnam Kore) 김윤근 (MD Healthcare Inc. Seoul Korea.) 김정희 (Department of Pediatrics Inha University College of Medicine Incheon Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.1
발행연도
2021.1
수록면
56 - 74 (19page)

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Purpose: Bacterial extracellular vesicles (EVs) play crucial roles in bacteria-host interactions. Due to their cargo, EVs are considered fingerprints of the parent cell, which are detectable in body fluids. We studied the composition and function of bacterial microbiota-derived EVs genes in urine to evaluate whether they have specific characteristics concerning allergic airway disease. Methods: Subjects were from elementary school surveys and classified into 3 groups according to questionnaires and sensitization to aeroallergens: the allergic airway group (AA, n = 16), atopic controls (AC, n = 7) and healthy controls (HC, n = 26). The bacterial EVs were isolated from voided urine samples, their nucleic acid was extracted for 16S ribosomal RNA pyrosequencing and then characterized using α-diversity, β-diversity, network analysis, intergroup comparison of bacterial composition and predicted functions, and correlation with total immunoglobulin E (IgE), eosinophils% and fractional exhaled NO. Results: The compositional α-diversity was the highest in AA, while functional α-diversity was the highest in HC. AA had a distinct clustering with the least intersample variation. Klebsiella, Haemophilus, members from Lachnospiraceae and Ruminococcaceae, and the pathways of sphingolipid and glycerolipid metabolism, and biosynthesis of peptidoglycan and lysine were the highest in AA and positively correlated with total IgE or eosinophil%. Genetic information processing function contributed to 48% of the intergroup variance and was the highest in AA. Diaphorobacter, Acinetobacter, and the pathways of short-chain fatty acids and anti-oxidants metabolism, lysine and xenobiotic degradation, and lipopolysaccharide biosynthesis were the lowest in AA and negatively correlated with total IgE or eosinophil%. The bacterial composition and function in AC were closer to those in HC. The bacterial network was remarkably dense in HC. Conclusions: The bacterial microbiota-derived EVs in urine possess characteristic features in allergic airway disease with a remarkable correlation with total IgE and eosinophil%. These findings suggest that they may play important roles in allergic airway diseases.
#Microbiota #bacteria #extracellular vesicles #metabolic networks and pathways #asthma #allergic rhinitis #hypersensitivity #child #urine

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참고문헌 (50)

참고문헌 신청
Gill S / 2019 / Extracellular membrane vesicles in the three domains of life and beyond / FEMS Microbiol Rev 43:273~303 google schola 김현정 / 2017 / The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients / Experimental and Molecular Medicine 49:1~8 dbpia Choi EB / 2014 / Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis / Allergy 69:517~526 google schola Yáñez-Mó M / 2015 / Biological properties of extracellular vesicles and their physiological functions / J Extracell Vesicles 4:27066 google schola Stremersch S / 2016 / Therapeutic and diagnostic applications of extracellular vesicles / J Control Release 244:167~183 google schola

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