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- 자료유형
- 학술저널
- 저자정보
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- 2020.1
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Mesenchymal stem cells (MSCs) have been reported to be promising candidates for the treatment of allergic airway diseases. However, MSCs themselves have several problems including immune rejection, risk of aneuploidy, difficulty of handling, and tumorigenicity. An increasing number of studies demonstrated that administration of conditioned media or extracellular vesicles (EVs) released by MSCs is as effective as the MSCs themselves in suppression of allergic airway inflammation. EVs can exert their effects by delivering their contents such as proteins, mRNAs, and microRNAs to recipient cells. Furthermore, the administration of MSCs-derived EVs may reduce potential safety risks associated with stem cell therapy, suggesting that MSCs-derived EVs may be a promising alternative to cell therapy for allergic airway diseases. This review examines the current understanding of the immunomodulatory properties of MSCs-derived EVs and its therapeutic implication for allergic airway diseases.
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참고문헌 (55)
참고문헌 신청
Uccelli A / 2008 / Mesenchymal stem cells in health and disease / Nat Rev Immumol 8:726~762
Tuan RS / 2003 / Adult mesenchymal stem cells and cellbased tissue engineering / Arthritis Res Ther 5:32~45
Law S / 2013 / Mesenchymal stem cell and regenerative medicine : regenerative versus immunomodulatory challenges / Am J Stem Cells 8:22~38
조규섭 / 2016 / 알레르기성 기도 질환의 동물모델에서 줄기 세포 치료 / Allergy Asthma & Respiratory Diseases 4(3):167~173
조규섭 / 2014 / 비과 영역에서 중간엽줄기세포의 적용 / 대한이비인후-두경부외과학회지 57(4):207~213
Tuan RS / 2003 / Adult mesenchymal stem cells and cellbased tissue engineering / Arthritis Res Ther 5:32~45
Law S / 2013 / Mesenchymal stem cell and regenerative medicine : regenerative versus immunomodulatory challenges / Am J Stem Cells 8:22~38
조규섭 / 2016 / 알레르기성 기도 질환의 동물모델에서 줄기 세포 치료 / Allergy Asthma & Respiratory Diseases 4(3):167~173
조규섭 / 2014 / 비과 영역에서 중간엽줄기세포의 적용 / 대한이비인후-두경부외과학회지 57(4):207~213
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