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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) are capable of differentiating into mesenchymal tissue such as bone, cartilage, muscle, and adipose, and have been isolated and characterized from various species. Deer adipose tissue-derived MSCs (dAD-MSCs) have not been studied and deer bone marrow-derived MSCs (dBM-MSCs) have not been fully characterized. In this study, we firstly isolated MSCs from deer tissues and then compared characteristics of dAD-MSCs and dBM-MSCs. dAD-MSCs and dBM-MSCs exhibited significant increase in proliferation under low-glucose DMEM culture condition during 20 and 10 passages consecutive passages, respectively. Both cells expressed cell surface markers such as CD73, CD90, and CD105, but did not express CD34 and CD45. Two types of cells expressed stemness markers (Oct4, Sox2, and Nanog) and exhibited differentiation potential into mesodermal lineages. Both cells exhibited osteogenic and chondrogenic differentiation potential, but poor adipogenic differentiation potential. Specifically, dAD-MSCs have a greater capacity for chondrogenic differentiation potential compared to dBM-MSCs. Collectively, we successfully isolated dAD-MSCs from deer for the first time. This study suggests that adipose tissue of deer could be used as a source of deer MSCs.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Barberini DJ / 2014 / Equine mesenchymal stem cells from bone marrow, adipose tissue and umbilical cord: immunophenotypic characterization and differentiation potential / Stem Cell Res Ther 5:25
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Butler DL / 2000 / Functional tissue engineering: the role of biomechanics / J Biomech Eng 122:570~575
Chung DJ / 2012 / Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia / Res Vet Sci 92:66~75
Daley EL / 2014 / Phenotypic differences in white-tailed deer antlerogenic progenitor cells and marrow-derived mesenchymal stromal cells / Tissue Eng Part A 20:1416~1425
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Butler DL / 2000 / Functional tissue engineering: the role of biomechanics / J Biomech Eng 122:570~575
Chung DJ / 2012 / Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia / Res Vet Sci 92:66~75
Daley EL / 2014 / Phenotypic differences in white-tailed deer antlerogenic progenitor cells and marrow-derived mesenchymal stromal cells / Tissue Eng Part A 20:1416~1425
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