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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Mesenchymal stem cells (MSCs) are multipotent cells capable of replicating as undifferentiated cells, and thus hold therapeutic implications in field of regenerative medicine and reproductive biotechnology. In the present study, we compared the stem cell properties of bovine ear skin tissue (ESK)- and nasal mucosa (NM)-derived MSCs. Bovine ESK-MSCs and NM-MSCs were successfully isolated by collagenase digestion and maintained proliferative capacity during the 20 consecutive passages. Both ESK-MSCs and NM-MSCs showed similar morphology and expressed common cell surface markers (CD29, CD44, CD90, and CD105). Also, we compared differentiation potentials of bovine ESK-MSCs and NM-MSCs into osteogenic, adipogenic, and chondrogenic lineages through specific staining and quantitative real-time RT-PCR. As results, bovine ESK-MSCs and NM-MSCs could differentiate into mesodermal cell lineages. However, bovine ESK-MSCs and NM-MSCs exhibited difference in expression of differentiation-related specific markers. Specifically, NM-MSCs exhibited increased expression levels of osteocalcin, peroxisome proliferator-activated receptor gamma, and aggrecan compared to ESK-MSCs. Also, ESK-MSCs exhibited increased expression levels of collagen type I, II, and lipoprotein lipase compared to NM-MSCs. We suggest that the nasal mucosa of bovine could be used as a source of bovine MSCs.
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참고문헌 (29)
참고문헌 신청
Asakura A / 2001 / Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation / Differentiation 68(4-5):245~253
Zuk PA / 2001 / Multilineage cells from human adipose tissue : implications for cell-based therapies / Tissue Eng 7(2):211~228
Balamurugan V / 2004 / Past and present vaccine development strategies for the control of foot-and-mouth disease / Acta Virol 48(4):201~214
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Cahuascanco B / 2019 / Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus aureus / Vet Res 50(1):25
Zuk PA / 2001 / Multilineage cells from human adipose tissue : implications for cell-based therapies / Tissue Eng 7(2):211~228
Balamurugan V / 2004 / Past and present vaccine development strategies for the control of foot-and-mouth disease / Acta Virol 48(4):201~214
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Cahuascanco B / 2019 / Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus aureus / Vet Res 50(1):25
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