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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 95 - 102 (8page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.3.95
이용수
초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) are multipotent cells able to differentiate into several cell lineages, which has implications for cell therapy and reproductive biotechnologies. Although MSCs have been isolated from many species, including humans and animals, there is limited data on MSCs from large ruminants, such as bovines. In this study, we tried to isolate and characterize bovine tongue tissue-derived MSCs (boT-MSCs) by investigating phenotype morphology, performing proliferation properties, and determining cell surface marker expression patterns, self-renewal, and differentiation potentials. As a result, the boT-MSCs were successfully isolated by collagenase digestion and maintained proliferative capacity until 20 passages. Moreover, the boT-MSCs expressed pluripotency markers (OCT3/4, SOX2, and NANOG) and MSC-specific surface markers including CD44, CD90, and CD105, but not CD45 and MHC-II. The boT-MSCs could also differentiate into mesodermal (adipocyte, osteocyte, and chondrocyte) cell lineages. Our results suggest that the tongues of bovines could be used as a source of MSCs.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Balamurugan V / 2004 / Past and present vaccine development strategies for the control of foot-and-mouth disease / Acta Virol 48:201~214
Bjornson CR / 1999 / Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo / Science 283:534~537
Brehm KE / 2009 / Highly sensitive fetal goat tongue cell line for detection and isolation of foot-and-mouth disease virus / J Clin Microbiol 47:3156~3160
Campagnoli C / 2001 / Identification of mesenchymal stem/ progenitor cells in human first-trimester fetal blood, liver, and bone marrow / Blood 98:2396~2402
Cardoso TC / 2017 / Isolation, characterization and immunomodulatory-associated gene transcription of Wharton's jelly-derived multipotent mesenchymal stromal cells at different trimesters of cow pregnancy / Cell Tissue Res 367:243~256
Bjornson CR / 1999 / Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo / Science 283:534~537
Brehm KE / 2009 / Highly sensitive fetal goat tongue cell line for detection and isolation of foot-and-mouth disease virus / J Clin Microbiol 47:3156~3160
Campagnoli C / 2001 / Identification of mesenchymal stem/ progenitor cells in human first-trimester fetal blood, liver, and bone marrow / Blood 98:2396~2402
Cardoso TC / 2017 / Isolation, characterization and immunomodulatory-associated gene transcription of Wharton's jelly-derived multipotent mesenchymal stromal cells at different trimesters of cow pregnancy / Cell Tissue Res 367:243~256
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