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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 24 - 31 (8page)
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Purpose: The differentiation properties of stem cells are not yet fully understood due to their close association with multiple environmental and extrinsic factors. This study investigates the differentiation properties of mesenchymal stem cells (MSCs) and correlates them with their intrinsic mechanical properties.
Methods: A total of 3 different types of MSCs, namely bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UCSCs), and adipose-derived MSCs (ADSCs) were evaluated. These 3 MSCs were individually differentiated into adipocytes and osteoblasts for 3 weeks. The mechanical properties of the MSCs and differentiated cells were determined by atomic force microscopy.
Results: ADSCs showed the greatest ability to differentiate into adipocytes, followed by BMSCs and UCSCs. While UCSCs differentiated readily into osteoblasts, BMSCs and ADSCs were less likely to undergo this differentiation. UCSCs were the “hardest” cells, while ADSCs were the “softest.” The cells differentiated from “hard” MSCs were stiffer than the cells differentiated from “soft” MSCs, irrespective of lineage specification.
Conclusions: The differentiation ability of MSCs and the mechanical properties of the differentiated cells were closely linked.
However, there were no significant correlations regarding changes in the mechanical properties between the nuclear region and the cytoplasm during differentiation.
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참고문헌 (24)
참고문헌 신청
Alhadlaq A / 2004 / Mesenchymal stem cells : isolation and therapeutics / Stem Cells Dev 13 : 436 ~ 448
Azizi SA / 1998 / Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats : similarities to astrocyte grafts / Proc Natl Acad Sci
Carvalho JL / 2013 / Priming mesenchymal stem cells boosts stem cell therapy to treat myocardial infarction / J Cell Mol Med 17 : 617 ~ 625
Chalut KJ / 2010 / Deformation of stem cell nuclei by nanotopographical cues / Soft Matter 6 : 1675 ~ 1681
Chen Q / 2010 / AFM studies of cellular mechanics during
Azizi SA / 1998 / Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats : similarities to astrocyte grafts / Proc Natl Acad Sci
Carvalho JL / 2013 / Priming mesenchymal stem cells boosts stem cell therapy to treat myocardial infarction / J Cell Mol Med 17 : 617 ~ 625
Chalut KJ / 2010 / Deformation of stem cell nuclei by nanotopographical cues / Soft Matter 6 : 1675 ~ 1681
Chen Q / 2010 / AFM studies of cellular mechanics during
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