Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders

Hernandez, Rosa; Jimenez-Luna, Cristina; Perales-Adan, Jesus; Perazzoli, Gloria; Melguizo, Consolacion; Prados, Jose

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자료유형: 학술저널

저자정보: Hernandez, Rosa (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada) Jimenez-Luna, Cristina (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada) Perales-Adan, Jesus (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada) Perazzoli, Gloria (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada) Melguizo, Consolacion (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada) Prados, Jose (Institute of Biopathology and Regenerative Medicine [IBIMER], Center of Biomedical Research [CIBM], University of Granada)

저널정보: 한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제28권 제1호

발행연도: 2020.1

수록면: 34 - 44 (11page)

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Mesenchymal stem cells (MSCs) have been proposed as an alternative therapy to be applied into several pathologies of the nervous system. These cells can be obtained from adipose tissue, umbilical cord blood and bone marrow, among other tissues, and have remarkable therapeutic properties. MSCs can be isolated with high yield, which adds to their ability to differentiate into non-mesodermal cell types including neuronal lineage both in vivo and in vitro. They are able to restore damaged neural tissue, thus being suitable for the treatment of neural injuries, and possess immunosuppressive activity, which may be useful for the treatment of neurological disorders of inflammatory etiology. Although the long-term safety of MSC-based therapies remains unclear, a large amount of both pre-clinical and clinical trials have shown functional improvements in animal models of nervous system diseases following transplantation of MSCs. In fact, there are several ongoing clinical trials evaluating the possible benefits this cell-based therapy could provide to patients with neurological damage, as well as their clinical limitations. In this review we focus on the potential of MSCs as a therapeutic tool to treat neurological disorders, summarizing the state of the art of this topic and the most recent clinical studies.

#Mesenchymal stem cells #Nervous system disorders #Cell-based therapy #Neuronal differentiation #Clinical trials

참고문헌 (97)

참고문헌 신청

Achanta, P. / 2010 / Gliomagenesis and the use of neural stem cells in brain tumor treatment / Anticancer Agents Med. Chem 10:121~130

Ahmadi, N. / 2012 / Stability of neural differentiation in human adipose derived stem cells by two induction protocols / Tissue Cell 44:87~94

Alexanian, A. R. / 2015 / Epigenetic modulators promote mesenchymal stem cell phenotype switches / Int. J. Biochem. Cell Biol 64:190~194

Alexanian, A. R. / 2013 / Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels / Int. J. Biochem. Cell Biol 45:1633~1638

Arboleda, D. / 2011 / Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury / Cell. Mol. Neurobiol 31:1113~1122

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