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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제37권 제3호
- 발행연도
- 2020.1
- 수록면
- 149 - 158 (10page)
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초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.
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참고문헌 (78)
참고문헌 신청
Gupta S / 2005 / The economic burden of disabling hip and knee osteoarthritis(OA)from the perspective of individuals living with this condition / Rheumatology(Oxford) 44:1531~1537
de Lange-Brokaar BJ / 2012 / Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review / Osteoarthritis Cartilage 20:1484~1499
Vincenti MP / 2002 / Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors / Arthritis Res 4:157~164
Roach HI / 2005 / Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions / Arthritis Rheum 52:3110~3124
Martin JA / 2003 / The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair / J Bone Joint Surg Am 85A(Suppl 2):106~110
de Lange-Brokaar BJ / 2012 / Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review / Osteoarthritis Cartilage 20:1484~1499
Vincenti MP / 2002 / Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors / Arthritis Res 4:157~164
Roach HI / 2005 / Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions / Arthritis Rheum 52:3110~3124
Martin JA / 2003 / The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair / J Bone Joint Surg Am 85A(Suppl 2):106~110
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