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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 1 - 9 (9page)
- DOI
- https://doi.org/10.13041/jpvm.2018.42.1.1
이용수
초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs), which are present in all tissues, can differentiate into cells with various specific functions. Recently, cell-based therapies using MSCs have been increasing in the veterinary research and related fields. In this study, we investigated the cellular morphology, proliferating capacities, expression of cell surface markers such as CD13, CD34, CD44, CD45, CD90, and CD105, mesodermal differentiation potentials, and expression of senescence-related markers of p53, p21, and telomerase reverse transcriptase in equine adipose tissue-derived MSCs (eAD-MSCs) after cryopreservation. The eAD-MSCs were analyzed immediately and after being frozen in liquid nitrogen for 1 year (< 1 year, G1) and more than 3 years (> 3 years, G2), respectively. After cryopreservation for 1 - 3 years, G2 eAD-MSCs showed similar cellular morphology, proliferating capacities, and expression of cell surface markers when compared with G1 eAD-MSCs. Moreover, cryopreservation did not affect the adipogenic, chondrogenic, or osteogenic differentiation potentials of G1 and G2 eAD-MSCs. Collectively, cryopreservation for (or over) 3 years maintained the stem cell phenotype and differentiation potentials of eAD-MSCs. These results will be an advantage that can be effectively used for future development of cell-based therapies.
목차
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참고문헌 (34)
참고문헌 신청
Aliouat-Denis CM / 2005 / p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2 / Mol Cancer Res 3:627~634
Bastos FZ / 2017 / Collection, processing and freezing of equine bone marrow cells / Cryobiology 78:95~100
Black LL / 2007 / Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter controlled trial / Vet Ther 8:272~284
Carvalho AD / 2011 / Use of adipose tissue-derived mesenchymal stem cells for experimental tendinitis therapy in equines / J Equine Vet Sci 31:26~34
Choi JS / 2015 / Effects of donor age, long-term passage culture, and cryopreservation on tonsil-derived mesenchymal stem cells / Cell Physiol Biochem 36:85~99
Bastos FZ / 2017 / Collection, processing and freezing of equine bone marrow cells / Cryobiology 78:95~100
Black LL / 2007 / Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter controlled trial / Vet Ther 8:272~284
Carvalho AD / 2011 / Use of adipose tissue-derived mesenchymal stem cells for experimental tendinitis therapy in equines / J Equine Vet Sci 31:26~34
Choi JS / 2015 / Effects of donor age, long-term passage culture, and cryopreservation on tonsil-derived mesenchymal stem cells / Cell Physiol Biochem 36:85~99
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