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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Mesenchymal stem cells (MSCs) are multipotent cells capable of replicating as undifferentiated cells, and have the potential of differentiating into mesodermal lineages. Goats are commonly used as animal models for bone tissue engineering to test the potential of stem cells for bone regeneration. Goat MSCs isolated from bone marrow (BM) or adipose tissue (AD) should be evaluated using in vitro assays, prior to their application in a tissue engineering project. In this study, we compared the stem cell properties of MSCs derived from goat AD, BM and ear skin tissue (ESK). As results, BM and ESK-MSCs exhibited a spindle-shaped morphology comparable to that of AD-MSCs. Especially, BM-MSCs could be cultured for significantly longer periods and exhibited the greatest expansion capacity, whereas AD-MSCs had the shortest culture time and lowest growth rate. Also, we compared differentiation potentials of AD, BM and ESK-MSCs into adipogenic, chondrogenic, and osteogenic lineages through specific staining and quantitative real-time RT-PCR. Collectively, we successfully isolated ESK-MSCs from goat for the first time. This study suggests that adult skin tissue of goat could be used as a source of goat MSCs. Further studies are needed to show the more information for establishment and fully characterization of goat ESK-MSCs.
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참고문헌 (26)
참고문헌 신청
Asakura A / 2001 / Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation / Differentiation 68:245~253
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Elkhenany H / 2016 / Impact of the source and serial passaging of goat mesenchymal stem cells on osteogenic differentiation potential: implications for bone tissue engineering / J Anim Sci Biotechnol 7:16
Friedenstein AJ / 1976 / Fibroblast precursors in normal and irradiated mouse hematopoietic organs / Exp Hematol 4:267~274
Heidari B / 2013 / Comparison of proliferative and multilineage differentiation potential of sheep mesenchymal stem cells derived from bone marrow, liver, and adipose tissue / Avicenna J Med Biotechnol 5:104~117
Becker AJ / 1963 / Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells / Nature 197:452~454
Elkhenany H / 2016 / Impact of the source and serial passaging of goat mesenchymal stem cells on osteogenic differentiation potential: implications for bone tissue engineering / J Anim Sci Biotechnol 7:16
Friedenstein AJ / 1976 / Fibroblast precursors in normal and irradiated mouse hematopoietic organs / Exp Hematol 4:267~274
Heidari B / 2013 / Comparison of proliferative and multilineage differentiation potential of sheep mesenchymal stem cells derived from bone marrow, liver, and adipose tissue / Avicenna J Med Biotechnol 5:104~117
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