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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 141 - 149 (9page)
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Background/Aims: Therapies involving bone-marrow-derived mesenchymal stem cells (BM-MSCs) have considerable potential in the management of hepatic disease. BM-MSCs have been investigated in regenerative medicine due to their ability to secrete various growth factors and cytokines that regress hepatic fibrosis and enhance hepatocyte functionality. The aim of this study was to determine the antifibrosis effect of BM-MSCs on activated hepatic stellate cells (HSCs) and the mechanism underlying how BM-MSCs modulate the function of activated HSCs.
Methods: We used HSCs in both direct and indirect co-culture systems with BM-MSCs to evaluate the antifibrosis effect of BM-MSCs. The cell viability and apoptosis were evaluated by a direct co-culture system of activated HSCs with BM-MSCs. The activations of both HSCs alone and HSCs with BM-MSCs in the direct co-culture system were observed by immunocytochemistry for alpha-smooth muscle actin (α-SMA). The levels of growth factors and cytokines were evaluated by an indirect co-culture system of activated HSCs with BM-MSCs.
Results: The BM-MSCs in the direct co-culture system significantly decreased the production of α-SMA and the viability of activated HSCs, whereas they induced the apoptosis of activated HSCs. The BM-MSCs in the indirect co-culture system decreased the production of transforming growth factor-β1 and interleukin (IL)-6, whereas they increased the production of hepatocyte growth factor and IL-10. These results confirmed that the juxtacrine and paracrine effects of BM-MSCs can inhibit the proliferative, fibrogenic function of activated HSCs and have the potential to reverse the fibrotic process by inhibiting the production of α-SMA and inducing the apoptosis of HSCs.
Conclusions: These results have demonstrated that BM-MSCs may exert an antifibrosis effect by modulating the function of activated HSCs. (Clin Mol Hepatol 2015;21:141-149)
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참고문헌 (21)
참고문헌 신청
Bataller R / 2001 / Hepatic stellate cells as a target for the treatment of liver fibrosis / Semin Liver Dis 21 : 437 ~ 451
Bataller R / 2005 / Liver fibrosis / J Clin Invest 115 : 209 ~ 218
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepa
Cho KA / 2011 / Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice / Liver international : official journal of the International Association fo
Dorshkind K / 1990 / Regulation of hemopoiesis by bone marrow stromal cells and their products / Annu Rev Immunol 8 : 111 ~ 137
Bataller R / 2005 / Liver fibrosis / J Clin Invest 115 : 209 ~ 218
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hepa
Cho KA / 2011 / Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice / Liver international : official journal of the International Association fo
Dorshkind K / 1990 / Regulation of hemopoiesis by bone marrow stromal cells and their products / Annu Rev Immunol 8 : 111 ~ 137
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