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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 113 - 120 (8page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.3.113
이용수
초록· 키워드
오류제보하기
Mesenchymal stem cells (MSCs) have restricted life spans in vitro and can therefore only be expanded for a limited number of cell divisions before entering a senescent state and unequivocally stopping proliferation. Several types of cell culture systems have been used for large-scale expansion of MSCs. A recent trend in cell culture has been the change from serum-use to serum-supplement media. This study was conducted to investigate the proliferative effects of vegetable resources (VR) on equine adipose tissue-derived mesenchymal stem cells (eAD-MSCs) in the absence of serum and their possible mechanisms of action. Regulation of cell cycling is a key process involved in the fate of stem cells, including renewal and differentiation. In this study, we observed that the viability of eAD-MSCs was increased significantly when treated with VR under serum-free conditions. We also observed that expression levels of cell cycling-related proteins such as p53 and p21 were decreased, and proliferating cell nuclear antigen increased significantly in response to treatment with VR in eAD-MSCs under serum-free conditions. Furthermore, expression levels of cell survival-related proteins were increased in response to treatment with VR in eAD-MSCs under serum-free conditions. Therefore, our results suggest that VR promotes proliferation of eAD-MSCs under serum-free conditions.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Chien KB / 2012 / Novel soy protein scaffolds for tissue regeneration: Material characterization and interaction with human mesenchymal stem cells / Acta Biomater 8:694~703
Clark KC / 2016 / Canine and Equine Mesenchymal Stem Cells Grown in Serum Free Media Have Altered Immunophenotype / Stem Cell Rev 12:245~256
Coppe JP / 2008 / Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppres / PLoS Biol 6:2853~2868
Erickson GA / 1991 / Viral contamination of fetal bovine serum used for tissue culture: risks and concerns / Dev Biol Stand 75:173~175
Fischer UM / 2009 / Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect / Stem Cells Dev 18:683~692
Clark KC / 2016 / Canine and Equine Mesenchymal Stem Cells Grown in Serum Free Media Have Altered Immunophenotype / Stem Cell Rev 12:245~256
Coppe JP / 2008 / Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppres / PLoS Biol 6:2853~2868
Erickson GA / 1991 / Viral contamination of fetal bovine serum used for tissue culture: risks and concerns / Dev Biol Stand 75:173~175
Fischer UM / 2009 / Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect / Stem Cells Dev 18:683~692
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