지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 28 - 36 (9page)
- DOI
- https://doi.org/10.13041/jpvm.2018.42.1.28
이용수
초록· 키워드
오류제보하기
Musculoskeletal disorders including fracture, tendonitis, osteoarthritis, and laminitis are common diseases in racehorses that can cause large economic losses in the racehorse industry. Mesenchymal stem cells (MSCs) are being applied as new clinical tools for treatment of musculoskeletal disorders of racehorses. To investigate the immunomodulatory effects of stem cell therapy, we analyzed the anti- and pro-inflammatory factors in peripheral blood mononuclear cells of racehorses before and after stem cell application using quantitative real-time RT-PCR. The expression levels of pro-inflammatory factors (CCL5, IFN-γ, IL-2, and IL-18) were decreased while those of anti-inflammatory factors (TIMP-1, IL-10, TGF-β1, and VEGF) were increased significantly after application of equine adipose tissue-derived MSCs (eAD-MSCs) to racehorses with fracture. Moreover, the expression levels of pro-inflammatory factors (IL-2, IL-18, and TNF-α) were decreased while those of anti-inflammatory factors (TIMP-1, TIMP-2, IL-10, TGF-β1, and VEGF) increased significantly after stem cell application of eAD-MSCs in racehorses with tendonitis. After evaluating immunomodulatory effects of stem cell therapy on equine musculoskeletal disorders such as fracture and tendonitis, our results showed that expression levels of pro-inflammatory factors were decreased, while those of anti-inflammatory factors increased significantly after stem cell application of eAD-MSCs. These findings suggest that the healing effects of the stem cell therapy might be due to its modulation of inflammatory factors.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Andrades JA / 1999 / A recombinant human TGF-beta1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells / Exp Cell Res 250:485~498
Brew K / 2010 / The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity / Biochim Biophys Acta 1803:55~71
Carvalho AD / 2011 / Use of adipose tissue-derived mesenchymal stem cells for experimental tendinitis therapy in equines / J Equine Vet Sci 31:26~34
Carvalho Ade M / 2013 / Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial / Stem Cell Res Ther 4:85
Del Buono A / 2013 / Metalloproteases and tendinopathy / Muscles Ligaments Tendons J 3:51~57
Brew K / 2010 / The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity / Biochim Biophys Acta 1803:55~71
Carvalho AD / 2011 / Use of adipose tissue-derived mesenchymal stem cells for experimental tendinitis therapy in equines / J Equine Vet Sci 31:26~34
Carvalho Ade M / 2013 / Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial / Stem Cell Res Ther 4:85
Del Buono A / 2013 / Metalloproteases and tendinopathy / Muscles Ligaments Tendons J 3:51~57
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