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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 43 - 53 (11page)
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The anticancer activity of guava (Psidium guajava L.) leaf extract (GLE) occurs via the induction of apoptosis in cancer cells. However, the mechanism behind GLE-induced apoptosis in the human hepatocellular carcinoma cell line HepG2 remains unclear. In the present study, we investigated the apoptotic effects and mechanism of action of GLE in cultured HepG2 cells. The results showed that GLE induced reactive oxygen species (ROS) synthesis and disrupted the mitochondrial membrane potential (ΔΨm). Moreover, GLE increased the expression of apoptotic pathway proteins, such as the cleaved forms of caspase-3, -8, and -9; the translocation of Bax and cytochrome c (cyt-c) from the mitochondria to the cytosol; and the downregulation of Bcl-2. In addition, p53 protein expression was increased upon GLE treatment. These observations indicate that the GLE-induced apoptosis in HepG2 cells is mediated by mitochondrial ROS generation, followed by caspase activation and cyt-c release, suggesting that GLE may be a promising candidate for the development of novel drugs for the treatment of liver cancers.
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참고문헌 (48)
참고문헌 신청
Zou Y / 2008 / The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells / Cancer Biol. Ther 7:691~698
Lee J / 2010 / Apoptotic activity of ethanol extract from Styrax Japonica Siebold et al. Zuccarini in HepG2 cells / J. Ethnopharmacol 131:210~215
Chen W / 2010 / α-Bisabolol induces dose-and time-dependent apoptosis in HepG2 cells via a Fas-and mitochondrial-related pathway, involves p53 and NF-κB / Biochem. Pharmacol 80:247~254
Nepal S / 2012 / Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction / Biochem. Pharmacol 84:974~983
Park C / 2012 / J7, a methyl jasmonate derivative, enhances TRAIL-mediated apoptosis through up-regulation of reactive oxygen species generation in human hepatoma HepG2 cells / Toxicol. In Vitro 26:86~93
Lee J / 2010 / Apoptotic activity of ethanol extract from Styrax Japonica Siebold et al. Zuccarini in HepG2 cells / J. Ethnopharmacol 131:210~215
Chen W / 2010 / α-Bisabolol induces dose-and time-dependent apoptosis in HepG2 cells via a Fas-and mitochondrial-related pathway, involves p53 and NF-κB / Biochem. Pharmacol 80:247~254
Nepal S / 2012 / Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction / Biochem. Pharmacol 84:974~983
Park C / 2012 / J7, a methyl jasmonate derivative, enhances TRAIL-mediated apoptosis through up-regulation of reactive oxygen species generation in human hepatoma HepG2 cells / Toxicol. In Vitro 26:86~93
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