지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Avian sex determination system involves the male ZZ and female ZW chromosomes. However, very few studies are reported the expression, functional role and importance of genes on the W chromosome because of its small and highly heterochromatic genomic regions. Recent studies demonstrated that the W chromosome may have critical roles in physiology, sex determination and subsequent sexual differentiation in chickens. Therefore, gene annotation, including describing the expression and function of genes in the chicken W chromosome, is needed. In this study, we have searched the W chromosome of chickens and selected a total of 36 genes to evaluated their specific expression in the testis and ovary at various developmental stages such as embryonic day 6 (E6), hatch and adult. Interestingly, out of 36 genes in chicken W chromosome, we have found seven female-specific expression at E6.5 day, indicating that they are functionally related to female chicken gonadal differentiation. In addition, we have identified the stage specific gene expression from the sex specific genes. Furthermore, we analyzed the relative location of genes in the chicken W chromosome. Collectively, these results will contribute molecular insights into the sexual determination, differentiation and female development based on the W chromosome.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Ayers KL / 2013 / RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome / Genome Biology 14(3):R26
Ayers KL / 2013 / The molecular genetics of ovarian differentiation in the avian model / Sex Dev 7(1-3):80~94
Bachtrog D / 2011 / Are all sex chromosomes created equal? / Trends in Genetics 27(9):350~357
Berlin S / 2007 / Low mitochondrial variability in birds may indicate Hill-Robertson effects on the W chromosome / Heredity 99(4):389~396
Chue J / 2011 / Sex determination and sexual differentiation in the avian model / FEBS J 278(7):1027~1034
Ayers KL / 2013 / The molecular genetics of ovarian differentiation in the avian model / Sex Dev 7(1-3):80~94
Bachtrog D / 2011 / Are all sex chromosomes created equal? / Trends in Genetics 27(9):350~357
Berlin S / 2007 / Low mitochondrial variability in birds may indicate Hill-Robertson effects on the W chromosome / Heredity 99(4):389~396
Chue J / 2011 / Sex determination and sexual differentiation in the avian model / FEBS J 278(7):1027~1034
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UCI(KEPA) : I410-ECN-0101-2020-527-000234008