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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.4
- 발행연도
- 2019.12
- 수록면
- 442 - 448 (7page)
- DOI
- 10.3746/pnf.2019.24.4.442
이용수
초록· 키워드
오류제보하기
Ultraviolet B (UVB) irradiation-induced photoaging leads to wrinkles, dryness, and skin roughness. UVB irradiation activates the production of reactive oxygen species (ROS) and stimulates the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway, which promotes expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. The current study aimed to assess the anti-photoaging activity of Agastache rugosa extract (ARE) on UVB-treated human dermal fibroblasts. ARE treatment reduced the overproduction of ROS and promoted mRNA expression of anti-oxidant enzymes. ARE treatment significantly inactivated the MAPK/AP-1 signaling pathway, which downregulated the expression of MMPs. Moreover, ARE promoted the production of type-I procollagen and upregulated mRNA expression of collagen genes. Additionally, ARE suppressed the expression of inflammatory cytokines, including interleukin (IL)-1, IL-6, and IL-8, by preventing expression of nuclear factor-kappa B. Collectively, our findings show that ARE could be a potential candidate for anti-photoaging treatment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
Bae JY / 2010 / Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation / Exp Dermatol 19:e182~e190
Bai B / 2015 / Intraperitoneally administered biliverdin protects against UVB-induced skin photo-damage in hairless mice / J Photochem Photobiol B 144:35~41
Bradley JR / 2008 / TNF-mediated inflammatory disease / J Pathol 214:149~160
Chen B / 2015 / Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-/Smad signaling suppression and inhibiting matrix metalloproteinase-1 / Mol Med Rep 11:3344~3348
Chen YT / 1990 / Flavonoids as superoxide scavengers and antioxidants / Free Radic Biol Med 9:19~21
Bai B / 2015 / Intraperitoneally administered biliverdin protects against UVB-induced skin photo-damage in hairless mice / J Photochem Photobiol B 144:35~41
Bradley JR / 2008 / TNF-mediated inflammatory disease / J Pathol 214:149~160
Chen B / 2015 / Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-/Smad signaling suppression and inhibiting matrix metalloproteinase-1 / Mol Med Rep 11:3344~3348
Chen YT / 1990 / Flavonoids as superoxide scavengers and antioxidants / Free Radic Biol Med 9:19~21
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