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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 211 - 217 (7page)
- DOI
- 10.9799/ksfan.2017.30.2.211
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초록· 키워드
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In the present study, we investigated the protective effect of various grain methanolic extracts against UVB-induced photo-aging in human skin fibroblasts. Various grain methanolic extracts were evaluated for their antioxidant compounds and activities. 2,2-Ddiphenyl-1-picryhydrazyl radical (DPPH) and ABTS 2,2-azino-bris-(3-ethylbenzoth iazoline-6-sulphonic acid) radical cation scavenging activities have been used to measure the relative antioxidant activities of extracts from grains. The content of total polyphenolics in the extracts were evaluated using spectrophotometric methods. Human skin fibroblast (Hs68) cells were pretreated with various grain methanolic extracts (25 μg/mL). Skin toxicity was simulated by exposing the cells to UVB (30 mJ/cm2) irradiation. In response to the UVB-irradiation, an increased amount of matrix metalloproteinases (MMPs) release was observed, whereas pretreatment of various grain methanolic extracts significantly inhibited the production of MMP-1 in Hs68 cells. We also found that pretreatment of the extracts significantly decreased UVB-induced reactive oxygen species and significantly increased total collagen content in Hs68 cells. These results provide that grains could be regarded as a potential ingredient in natural cosmetics, used for UVB protection.
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참고문헌 (21)
참고문헌 신청
Chatterjee R / 1990 / Chronic ultraviolet B radiation-induced biochemical changes in the skin of hairless mice / Photochem Photobiol 51:91~97
Choi Y / 2007 / Antioxidant activity of methanolic extracts from some grains consumed in Korea / Food Chem 103:1~9
Dewanto V / 2002 / Processed sweet corn has higher antioxidant activity / J Agric Food Chem 50:1~6
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138:1462~1470
Fisher GJ / 1998 / Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo / J Clin Invest 101:1432~1440
Choi Y / 2007 / Antioxidant activity of methanolic extracts from some grains consumed in Korea / Food Chem 103:1~9
Dewanto V / 2002 / Processed sweet corn has higher antioxidant activity / J Agric Food Chem 50:1~6
Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138:1462~1470
Fisher GJ / 1998 / Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo / J Clin Invest 101:1432~1440
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