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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.4
- 발행연도
- 2019.12
- 수록면
- 492 - 497 (6page)
- DOI
- 10.3746/pnf.2019.24.4.492
이용수
초록· 키워드
오류제보하기
Benign prostatic hyperplasia (BPH) is an age-related disease characterized by prostatic enlargement and is the most common urologic symptoms in elderly men 60 years of age and older. Previously, we documented that 70% ethanol (EtOH) seed extract of Quisqualis indica (QI) attenuates pathological condition of testosterone propionate (TP)-induced BPH rat model via modulation of proliferation and apoptosis of prostate cells. Based on this potential of QI, we produced standardized seed extract of QI (HU-033) in order to prove further mechanisms. In this study, we aimed to suggest further mechanisms underlying the relationship between BPH and HU-033. Through not only cellular and nuclear receptor functional assays, but TP-mediated BPH rat model treated with HU-033, we demonstrated that HU-033 exerted antagonist effect on 1A- and 1D-adrenergic receptors in vitro and inhibitory effect on protein expression of androgen receptor and estrogen receptor alpha in vivo. Taken together, these results suggest that HU-033 is a novel candidate for the management of BPH.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Bartsch G / 2002 / Dihydrotestosterone and the role of 5 alpha-reductase inhibitors in benign prostatic hyperplasia / Urologe A 41:412~424
Brunet A / 2014 / Epigenetics of aging and aging-related disease / J Gerontol A Biol Sci Med Sci 69:S17
Carson C / 2003 / The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61:2~7
Chapple CR / 2005 / A comparison of varying alpha-blockers and other pharmacotherapy options for lower urinary tract symptoms / Rev Urol 4:S22~S30
Chon JK / 1999 / Alpha 1-adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia / J Urol 161:2002~2008
Brunet A / 2014 / Epigenetics of aging and aging-related disease / J Gerontol A Biol Sci Med Sci 69:S17
Carson C / 2003 / The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61:2~7
Chapple CR / 2005 / A comparison of varying alpha-blockers and other pharmacotherapy options for lower urinary tract symptoms / Rev Urol 4:S22~S30
Chon JK / 1999 / Alpha 1-adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia / J Urol 161:2002~2008
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