지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 9 - 20 (12page)
- DOI
- 10.7783/KJMCS.2020.28.1.9
이용수
초록· 키워드
오류제보하기
Background: Although a number of Panax ginseng cultivars have been developed by Korean researchers in recent years, there has been insufficient analysis of their beneficial properties. In this study, we sought to identify useful ginseng varieties as functional materials.
Methods and Results: We evaluated effects of root extracts of 10 ginseng cultivars (Cheongsun; CS, Chunpoong; CP, Gopoong; GP, Gumpoong; GMP, K1, Sunhyang; SH, Sunone; SO, Sunpoong; SP, Sunun; SU and Yunpoong; YP) against the inhibitory effects of nitric oxide (NO) and reactive oxygen species (ROS) production in mouse brain microglial BV2 cells, as well as the binding of N-methyl-D-aspartate receptor (NMDAR), a marker related to memory. Ginsenosides, such as 20 (S)-protopanaxadiols (PPDs), including ginsenoside-Rb1, -Rb2, -Rb3, -Rc, -Rd, and - Rg3 and 20 (S)-protopanaxatriols (PPTs) including -Re, -Rg1, and -Rg2 were analyzed by HPLC. We observed that the cultivar GMP showed the highest inhibitory effect (60.8%) against NO production at 20 ㎍/㎖. Those cultivars showing the significantly highest inhibition effects against ROS at 20 ㎍/㎖ were K1 (57.3%), SP (54.5%), YP (53.1%), CP (51.7%), CS (50.9%) and SH (49.6%). At 50 ㎍/㎖, K1 showed the most potent inhibitory effect (51.2%) on NMDAR binding. The total phenol content of SH (1.89 ㎎/g) and K1 (1.73 ㎎/g) were higher than those of the other cultivars, whereas in terms of PD/PT ratios, the values of CP (0.98), K1 (1.05) and SO (1.05) were lower than those of the other cultivars. On the basis of correlation coefficient (0.7064) between NMDAR inhibition and ONOO<SUP>−</SUP><SUP></SUP> scavenging activity.
Conclusions: The findings of this study indicate that the cultivars K1 and SH could be useful ginseng resources as functional materials with favorable cognition-improving and antioxidative properties.
Methods and Results: We evaluated effects of root extracts of 10 ginseng cultivars (Cheongsun; CS, Chunpoong; CP, Gopoong; GP, Gumpoong; GMP, K1, Sunhyang; SH, Sunone; SO, Sunpoong; SP, Sunun; SU and Yunpoong; YP) against the inhibitory effects of nitric oxide (NO) and reactive oxygen species (ROS) production in mouse brain microglial BV2 cells, as well as the binding of N-methyl-D-aspartate receptor (NMDAR), a marker related to memory. Ginsenosides, such as 20 (S)-protopanaxadiols (PPDs), including ginsenoside-Rb1, -Rb2, -Rb3, -Rc, -Rd, and - Rg3 and 20 (S)-protopanaxatriols (PPTs) including -Re, -Rg1, and -Rg2 were analyzed by HPLC. We observed that the cultivar GMP showed the highest inhibitory effect (60.8%) against NO production at 20 ㎍/㎖. Those cultivars showing the significantly highest inhibition effects against ROS at 20 ㎍/㎖ were K1 (57.3%), SP (54.5%), YP (53.1%), CP (51.7%), CS (50.9%) and SH (49.6%). At 50 ㎍/㎖, K1 showed the most potent inhibitory effect (51.2%) on NMDAR binding. The total phenol content of SH (1.89 ㎎/g) and K1 (1.73 ㎎/g) were higher than those of the other cultivars, whereas in terms of PD/PT ratios, the values of CP (0.98), K1 (1.05) and SO (1.05) were lower than those of the other cultivars. On the basis of correlation coefficient (0.7064) between NMDAR inhibition and ONOO<SUP>−</SUP><SUP></SUP> scavenging activity.
Conclusions: The findings of this study indicate that the cultivars K1 and SH could be useful ginseng resources as functional materials with favorable cognition-improving and antioxidative properties.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (54)
참고문헌 신청
안인옥 / 2008 / 인삼 신품종의 뿌리부위별 진세노사이드 함량 및 패턴비교 / Journal of Ginseng Research 32(1):15~18
Ambriz-Pérez DL / 2016 / Phenolic compounds: Natural alternative in inflammation treatment. a review / Cogent Food and Agriculture 2:1131412
Attele AS / 2002 / Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component / Diabetes 51:1851~1858
Boje KM / 1992 / Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death / Brain Research 587:250~256
Carvajal FJ / 2016 / Role of NMDA receptor-mediated glutamatergic signaling in chronic and acute neuropathologies / Neural Plasticity :2701526
Ambriz-Pérez DL / 2016 / Phenolic compounds: Natural alternative in inflammation treatment. a review / Cogent Food and Agriculture 2:1131412
Attele AS / 2002 / Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component / Diabetes 51:1851~1858
Boje KM / 1992 / Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death / Brain Research 587:250~256
Carvajal FJ / 2016 / Role of NMDA receptor-mediated glutamatergic signaling in chronic and acute neuropathologies / Neural Plasticity :2701526
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UCI(KEPA) : I410-ECN-0101-2020-480-000475334