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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Recently, decades of robust researches on degenerative brain disorder have been highlighted on the interactive connection of gut and brain. In terms of inflammatory cytokine production, others have shown that Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) is involved with Leucine-Rich Repeat Kinase 2 (LRRK2). HEK293T cells were transiently co-transfected with Myc-tagged LRRK2 and Flag-tagged NOD2 and then followed by co-immunoprecipitation assay. In this study, we provide the novel finding of physical protein-protein interaction between NOD2 and LRRK2. G2019S variant has shown stronger interactions against NOD2 than those of wild type LRRK2. In an axis of NOD2-LRRK2 communication, it is believed to pave a new way in the understanding of the bidirectional molecular mechanism of brain disorder, including Parkinson"s disease into gut inflammatory disease, including Crohn"s disease.
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참고문헌 (10)
참고문헌 신청
Ananthakrishnan AN / 2018 / Environmental triggers in IBD : a review of progress and evidence / Nat Rev Gastro Hepat 15:39
Cryan JF / 2015 / Gut microbiota : Microbiota and neuroimmune signalling-Metchnikoff to microglia / Nat Rev Gastro Hepat 12:494~496
Cummings JL / 1992 / Depression and Parkinson's disease : a review / Am J of Psychiatry 149:443~454
Gareau MG / 2014 / Microbiota-gut-brain axis and cognitive function / Adv Exp Med Biol 817:357~371
Park S / 2013 / p62/SQSTM1enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization / PLoS One 8:e57138
Cryan JF / 2015 / Gut microbiota : Microbiota and neuroimmune signalling-Metchnikoff to microglia / Nat Rev Gastro Hepat 12:494~496
Cummings JL / 1992 / Depression and Parkinson's disease : a review / Am J of Psychiatry 149:443~454
Gareau MG / 2014 / Microbiota-gut-brain axis and cognitive function / Adv Exp Med Biol 817:357~371
Park S / 2013 / p62/SQSTM1enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization / PLoS One 8:e57138
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NOD-Like Receptors in Infection, Immunity, and Diseases
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The Protein-Protein Interaction Network of Hereditary Parkinsonism Genes Is a Hierarchical Scale-Free Network
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Mouse models for brain disease preclinical study
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UCI(KEPA) : I410-ECN-0101-2020-510-000511918