지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 299 - 309 (11page)
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to investigate the effect of pre-applied orthodontic force on the regeneration of periodontal ligament (PDL) tissues and the underlying mechanisms in tooth replantation. Methods: Orthodontic force (50 cN) was applied to the left maxillary first molars of 7-week-old male Sprague–Dawley rats (n = 32); the right maxillary first molars were left untreated to serve as the control group. After 7 days, the first molars on both sides were fully luxated and were immediately replanted in their original sockets. To verify the effects of the pre-applied orthodontic force, we assessed gene expression by using microarray analysis and real-time reverse transcription polymerase chain reaction (RT-PCR), cell proliferation by using proliferating cell nuclear antigen (PCNA) immunofluorescence staining, and morphological changes by using histological analysis. Results: Application of orthodontic force for 7 days led to the proliferation of PDL tissues, as verified on microarray analysis and PCNA staining. Histological analysis after replantation revealed less root resorption, a better arrangement of PDL fibers, and earlier regeneration of periodontal tissues in the experimental group than in the control group. For the key genes involved in periodontal tissue remodeling, including CXCL2, CCL4, CCL7, MMP3, PCNA, OPG, and RUNX2, quantitative RT-PCR confirmed that messenger RNA levels were higher at 1 or 2 weeks in the experimental group. Conclusions: These results suggest that the application of orthodontic force prior to tooth replantation enhanced the proliferation and activities of PDL cells and may lead to higher success rates with fewer complications.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Thilander B / 2001 / Orthodontic aspects of the use of oral implants in adolescents : a 10-year follow-up study / Eur J Orthod 23:715~731
Schwartz O / 1987 / Allotransplantation of human teeth. A retrospective study of 73transplantations over a period of 28 years / Int J Oral Maxillofac Surg 16:285~301
Andreasen JO / 2007 / Textbook and color atlas of traumatic injuries to the teeth / Blackwell Munksgaard :740~760
Andreasen JO / 1990 / A long-term study of 370 autotransplanted premolars. Part III. Periodontal healing subsequent to transplantation / Eur J Orthod 12:25~37
Andreasen JO / 1981 / Periodontal healing after replantation and autotransplantation of incisors in monkeys / Int J Oral Surg 10:54~61
Schwartz O / 1987 / Allotransplantation of human teeth. A retrospective study of 73transplantations over a period of 28 years / Int J Oral Maxillofac Surg 16:285~301
Andreasen JO / 2007 / Textbook and color atlas of traumatic injuries to the teeth / Blackwell Munksgaard :740~760
Andreasen JO / 1990 / A long-term study of 370 autotransplanted premolars. Part III. Periodontal healing subsequent to transplantation / Eur J Orthod 12:25~37
Andreasen JO / 1981 / Periodontal healing after replantation and autotransplantation of incisors in monkeys / Int J Oral Surg 10:54~61
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UCI(KEPA) : I410-ECN-0101-2020-515-000537688