지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Nadolol is a β-blocker drug, which effectively manages hypertension and angina pectoris. Its chemical structure allows the formation of four possible stereoisomers. A coupled column high-performance liquid chromatographic (HPLC) system with UV and fluorescence detection was investigated for simultaneously determining four nadolol enantiomers in human plasma. The plasma samples were prepared using a convenient liquid-liquid extraction process and passed through HPLC. Nadolol was initially separated from the endogenous compounds or other impurities in human plasma on a Phenomenex silica column, and its enantiomers were resolved and determined on a Chirapak AD-H column. The developed HPLC method achieved an effective chiral separation and significantly eliminated endogenous compound interference. This optimal HPLC method was validated following FDA guidelines. The results showed good selectivity, linearity, accuracy (90.50 % – 105.27 %), and precision (RSDs < 9.52 %) for each enantiomer. This method was also successfully applied to determine nadolol enantiomers in the plasma samples of a healthy male volunteer (after orally administering 80 mg racemic nadolol), proving its suitability for nadolol stereoselective pharmacokinetic studies.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (19)
참고문헌 신청
X. Wang and C. B. Ching, J. Chromatogr. A, 1035, 167- 176 (2004).
R. Ci?marikova, L. Habala, J. Valentova and M. Markuliak, Appl. Sci., 9, 625 (2019).
B. S. Sekhon, Int. J. Pharmtech. Res., 2, 1584-1594 (2010).
X. Wang and C. B. Ching, Chirality, 14, 798-805 (2002).
X. Wang and C. B. Ching, J. Sep. Sci., 30, 333-343 (2007).
R. Ci?marikova, L. Habala, J. Valentova and M. Markuliak, Appl. Sci., 9, 625 (2019).
B. S. Sekhon, Int. J. Pharmtech. Res., 2, 1584-1594 (2010).
X. Wang and C. B. Ching, Chirality, 14, 798-805 (2002).
X. Wang and C. B. Ching, J. Sep. Sci., 30, 333-343 (2007).
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UCI(KEPA) : I410-ECN-0101-2020-433-000508580