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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 136 - 141 (6page)
- DOI
- 10.15188/kjopp.2020.06.34.3.136
이용수
초록· 키워드
오류제보하기
The purpose of this study was to investigate the action mechanism of the roots of Adenophora triphylla var. japonica extract (ATE) in 3T3-L1 adipocytes. Cell toxicity test by MTT assay and lipid accumulation was performed to evaluate the inhibitory effect on the differentiation of adipocyte from preadipocytes induced by MDI differentiation medium, while adipogenesis related proteins expression level were evaluated by western blotting. As a result, ATE inhibited MDI-induced adipocyte differentiation in 3T3-L1 cells dose-dependently without cytotoxicity. Our results showed that ATE inhibited the phosphorylation of IRS1, thereby decreasing the expression of PI3K110α and reducing the phosphorylation of AKT and mTOR, resulting in attenuated protein expression of C/EBPα, PPARγ, ap2 and FAS in 3T3-L1 cells. These results suggest anti-adipogenic functions for ATE, and identified IRS1 as a novel target for ATE in adipogenesis.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (30)
참고문헌 신청
Giri S / 2006 / AICAR inhibit adipocyte differentiation in 3T3L1 and restores metabolic alteractions in diet-induced obesity mice model / Nutr Metab 3(1):31~50
Kim SK / 2010 / Anti-adipogenic effect of dioxinodehydoeckol via AMPK activation in 3T3-L1 adipocytes / Chem Biol 186(1):24~29
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404(6778):635~643
Kang SI / 2015 / Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes / Biol Pharm Bull 38(4):552~558
Park JY / 2014 / Inhibition of adipogenesis by oligonol through Akt-mTOR inhibition in 3T3-L1 adipocytes / Evidence-Based Complementary and Alternative Medicine 2014
Kim SK / 2010 / Anti-adipogenic effect of dioxinodehydoeckol via AMPK activation in 3T3-L1 adipocytes / Chem Biol 186(1):24~29
Kopelman PG / 2000 / Obesity as a medical problem / Nature 404(6778):635~643
Kang SI / 2015 / Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes / Biol Pharm Bull 38(4):552~558
Park JY / 2014 / Inhibition of adipogenesis by oligonol through Akt-mTOR inhibition in 3T3-L1 adipocytes / Evidence-Based Complementary and Alternative Medicine 2014
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UCI(KEPA) : I410-ECN-0101-2020-519-000889058