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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.4
- 수록면
- 131 - 142 (12page)
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초록· 키워드
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Sestrin2 (Sesn2), a metabolic regulator, accumulates in response to a diverse array of cellular stresses. Sesn2 regulates cellular metabolism by inhibiting the mammalian target of rapamycin complex 1 through the AMP-activated protein kinase (AMPK) signaling pathway. Recently, researchers reported that Sesn2 regulates the differentiation and function of innate immune cells and T cells; however, the role of Sesn2 in B cells is largely unknown. In this study, we investigated the role of Sesn2 in Ig class switching and Ig production in mouse B cells. We observed that mouse B cells express Sesn2 mRNA. Interestingly, the expression of germline ε transcripts (GLTε) was selectively decreased in lipopolysaccharide-stimulated Sesn2<SUP>−/−</SUP> splenocytes. Overexpression of Sesn2 increased GLTε promoter activity in B cells. In addition, AICAR (an activator of AMPK) selectively increased IL-4-induced GLTε expression and surface IgE (sIgE) expression in splenocytes. Furthermore, AICAR selectively enhanced IL-4-induced GLTε expression, sIgE expression, and IgE production by anti-CD40-stimulated B cells. We observed that ovalbumin (OVA)-specific IgE concentration was reduced in OVA-challenged Sesn2<SUP>−/−</SUP> mice. Taken together, these results indicate that Sesn2-AMPK signaling selectively enhances IL-4-induced IgE class switching and IgE production by B cells, suggesting that this could be a therapeutic strategy targeting Sesn2 in IgE-mediated allergic diseases.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
Sanli T / 2012 / Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells / PLoS One 7:e32035
Chen SD / 2019 / Emerging roles of sestrins in neurodegenerative diseases : counteracting oxidative stress and beyond / J Clin Med 8:e1001
Wang LX / 2019 / Sestrin2 : its potential role and regulatory mechanism in host immune response in diseases / Front Immunol 10:2797
Sánchez-Álvarez M / 2019 / Sestrins as a therapeutic bridge between ROS and autophagy in cancer / Cancers(Basel) 11:e1415
Wang M / 2017 / Recent insights into the biological functions of sestrins in health and disease / Cell Physiol Biochem 43:1731~1741
Chen SD / 2019 / Emerging roles of sestrins in neurodegenerative diseases : counteracting oxidative stress and beyond / J Clin Med 8:e1001
Wang LX / 2019 / Sestrin2 : its potential role and regulatory mechanism in host immune response in diseases / Front Immunol 10:2797
Sánchez-Álvarez M / 2019 / Sestrins as a therapeutic bridge between ROS and autophagy in cancer / Cancers(Basel) 11:e1415
Wang M / 2017 / Recent insights into the biological functions of sestrins in health and disease / Cell Physiol Biochem 43:1731~1741
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UCI(KEPA) : I410-ECN-0101-2020-517-000894400