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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제25권 제2호
- 발행연도
- 2020.1
- 수록면
- 112 - 117 (6page)
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초록· 키워드
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Purpose: Oral supplementation of vitamin D can be inefficient in patients with vitamin D deficiency caused by intestinal malabsorption. This study investigated the efficacy and safety of parenteral vitamin D supplementation in infants and children with vitamin D deficiency caused by intestinal malabsorption. Methods: This study included 11 patients with vitamin D deficiency who were unresponsive to oral vitamin D or were unable to try oral vitamin D therapy due to underlying conditions. All patients were treated with weekly intramuscular injection of cholecalciferol 50,000 IU. Radiological findings and biochemical parameters including serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D3 (25(OH)D3), and parathyroid hormone levels were reviewed retrospectively. Results: Underlying diseases included small bowel atresia (n=3), necrotizing enterocolitis (n=3), congenital megacolon (n=2), chronic intestinal pseudo-obstruction (n=1), congenital mesenteric band (n=1), and Crohn disease (n=1). Three patients exhibited rickets on X-ray findings. The mean duration of treatment was 4.8±2.9 weeks. The alkaline phosphatase levels were decreased from 710±650 IU/L to 442±284 IU/L (P=0.143). The 25(OH)D3 level was increased from 6.0±3.4 ng/mL to 50.4±28.8 ng/mL (P=0.008) after 3 months. Two patients with rickets showed improved radiologic findings after parenteral treatment. Conclusion: Parenteral vitamin D therapy was effective and safe in patients with vitamin D deficiency caused by intestinal malabsorption. Long-term follow-up is needed to establish the efficacy of parenteral vitamin D therapy in a large number of patients.
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참고문헌 (23)
참고문헌 신청
Bouillon R / 2018 / Vitamin D insufficiency : definition, diagnosis and management / Best Pract Res Clin Endocrinol Metab 32:669~684
Choi HS / 2011 / Vitamin D insufficiency in Korea--a greater threat to younger generation : the Korea National Health and Nutrition Examination Survey(KNHANES)2008 / J Clin Endocrinol Metab 96:643~651
Maiya S / 2008 / Hypocalcaemia and vitamin D deficiency : an important, but preventable, cause of life-threatening infant heart failure / Heart 94:581~584
Allgrove J / 2015 / A Practical approach to Vitamin D deficiency and rickets / Endocr Dev 28:119~133
Munns CF / 2016 / Global consensus recommendations on prevention and management of nutritional rickets / J Clin Endocrinol Metab 101:394~415
Choi HS / 2011 / Vitamin D insufficiency in Korea--a greater threat to younger generation : the Korea National Health and Nutrition Examination Survey(KNHANES)2008 / J Clin Endocrinol Metab 96:643~651
Maiya S / 2008 / Hypocalcaemia and vitamin D deficiency : an important, but preventable, cause of life-threatening infant heart failure / Heart 94:581~584
Allgrove J / 2015 / A Practical approach to Vitamin D deficiency and rickets / Endocr Dev 28:119~133
Munns CF / 2016 / Global consensus recommendations on prevention and management of nutritional rickets / J Clin Endocrinol Metab 101:394~415
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