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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.29 No.4
- 발행연도
- 2020.1
- 수록면
- 270 - 280 (11page)
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초록· 키워드
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The prevalences of metabolic syndrome (MetS) and vitamin D deficiency are increasing dramatically worldwide. MetS is a major challenge because it can increase the risk of most non-communicable diseases. The beneficial effect of vitamin D on MetS components remains controversial, so the present review focused on the clinical effects of vitamin D supplementation on MetS components. Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and lanosterol 14 α-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation. We tried to elucidate and analyze almost all evidence from randomized controlled trial studies of the efficacy of vitamin D supplementation in patients with MetS. The findings of the present study reported beneficial effects of vitamin D supplementation on mentioned factors. Vitamin D supplementation is recommended in people with vitamin D deficiency even if it has no considerable effect on most MetS factors. However, existing data from interventional studies are insufficient to reach a definitive conclusion about the effect of vitamin D supplementation on MetS components in patients without vitamin D deficiency. Thus, new clinical studies are needed to test the hypothesis that vitamin D supplementation could alleviate MetS components in patients with sufficient intake of vitamin D.
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참고문헌 (84)
참고문헌 신청
Lopes HF / 2016 / Visceraladiposity syndrome / Diabetol Metab Syndr 8:40
Prasad P / 2016 / Interplay of vitamin D and metabolic syndrome : a review / Diabetes Metab Syndr 10:105~112
Moazzen H / 2017 / Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome:a double-blinded, randomized crossover controlled trial / Plant Foods Hum Nutr 72:126~133
Samson SL / 2014 / Metabolic syndrome / Endocrinol Metab Clin North Am 43:1~23
Kaur J / 2014 / A comprehensive review on metabolic syndrome / Cardiol Res Pract 2014:943162
Prasad P / 2016 / Interplay of vitamin D and metabolic syndrome : a review / Diabetes Metab Syndr 10:105~112
Moazzen H / 2017 / Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome:a double-blinded, randomized crossover controlled trial / Plant Foods Hum Nutr 72:126~133
Samson SL / 2014 / Metabolic syndrome / Endocrinol Metab Clin North Am 43:1~23
Kaur J / 2014 / A comprehensive review on metabolic syndrome / Cardiol Res Pract 2014:943162
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