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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Despite daily vitamin D recommendations, women with osteoporosis may not achieve optimal 25-hydroxy-vitamin D (25[OH]D) levels. We retrospectively evaluated the effect of education and vitamin D supplementation (1,000 IU/day) in Korean women with osteoporosis. Methods: Sixty-one women with osteoporosis who were taking cholecalciferol (800-1,000 IU/day) were enrolled during 2011 to 2012. Forty patients (education only, Edu group) were educated on the importance of >30 min sunlight exposure daily while taking vitamin D. Twenty-one patients (education with vitamin D supplementation, Add group) were prescribed 1,000 IU/day cholecalciferol (total 1,800-2,000 IU/day) plus education. Patients were divided into 3 groups according to serum 25(OH)D status: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (≥30 ng/mL). Furthermore, 25(OH)D levels were compared at baseline and after intervention for 3 months. Results: The median (interquartile range) serum 25(OH)D concentration at baseline was 25.10 (18.95-33.60) ng/mL. The mean (±standard error) differences in 25(OH)D levels from baseline to post-intervention were 19.85±3.86 and 31.73±4.82 ng/mL in the Edu group and Add group, respectively. Eighteen patients (29.5%) had vitamin D deficiency, 25 (41.0%) had insufficiency, and 18 (29.5%) had sufficient levels. Optimal 25(OH)D (30 ng/mL or more) was achieved in 54.5% and 95.2% patients in the Edu group and Add group, respectively (P=0.003). Conclusions: We consider that vitamin D concentration should be measured on a regular basis in order to maintain an optimal level of vitamin D concentration, and education and supplementation is needed if not sufficient.
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참고문헌 (15)
참고문헌 신청
Holick MF / 2007 / Vitamin D deficiency / N Engl J Med 357:266~281
Parfitt AM / 1990 / Metabolic bone disease and clinically related disorders / W.B. Saunders Company :329~396
Sahota O / 1995 / Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis / Clin Endocrinol (Oxf) 51
Malavolta N / 2005 / The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women / Osteoporos Int 16:1691~1697
김경민 / 2015 / Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research / 대한골대사학회지 22(4):143~149
Parfitt AM / 1990 / Metabolic bone disease and clinically related disorders / W.B. Saunders Company :329~396
Sahota O / 1995 / Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis / Clin Endocrinol (Oxf) 51
Malavolta N / 2005 / The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women / Osteoporos Int 16:1691~1697
김경민 / 2015 / Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research / 대한골대사학회지 22(4):143~149
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