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논문 기본 정보

자료유형
학술저널
저자정보
Park Ji Soo (Department of Pediatrics Seoul National University Hospital Seoul National University College of Medicine Seoul Korea.) Kim Mina (Department of Statistics Graduate School of Chung-Ang University Seoul Korea.) Sol In Suk (Department of Pediatrics Severance Hospital Yonsei University College of Medicine Seoul Korea.) Lee Kyung Suk (Department of Pediatrics Hanyang University Guri Hospital Hanyang University College of Medicine Guri Korea.) Park Suyeon (Department of Biostatistics Soonchunhyang University Seoul Hospital Seoul Korea.Department of Applied Statistics Chung-Ang University Seoul Korea.) Yang Hyeon-Jong (Department of Pediatrics Soonchunhyang University Seoul Hospital Soonchunhyang University College of Medicine Seoul Korea.) Lee Eun (Department of Pediatrics Chonnam National University Hospital Chonnam National University Medical School Gwangju Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.2
발행연도
2023.3
수록면
262 - 270 (9page)
DOI
10.4168/aair.2023.15.2.262

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Various therapeutic approaches, including supplemental nutritional support, have been tried for the treatment of atopic dermatitis (AD). Previous studies have reported the role of vitamin D in the treatment of AD with inconsistent results. The aim of this study was to evaluate the effectiveness of vitamin D in the treatment of AD, with considerations on the heterogeneities of AD. Randomized controlled trials (RCTs) on the efficacy of vitamin D supplementation for AD treatment, published before June 30, 2021 were identified in the PubMed, EMBASE, MEDLINE, and Cochrane Library databases. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation system. This meta-analysis included 5 RCTs with 304 cases of AD. We found that vitamin D supplementation did not decrease AD severity, even when AD was classified as severe vs non-severe. However, vitamin D supplementation was found to be effective in the treatment of AD in RCTs that included both children and adults, but not in those that included only children. Geographic location was associated with a significant difference in the therapeutic effect of vitamin D supplementation. Moreover, vitamin D supplementation of > 2,000 IU/day decreased AD severity, but supplementation ≤ 2,000 IU/day did not. Vitamin D supplementation, in general, was not effective for the treatment of AD. However, vitamin D supplementation might provide a therapeutic effect depending on the geographic location and dose of supplementation. The results of the present meta-analysis suggest that vitamin D supplementation might be targeted for patients with AD who may benefit from vitamin D supplementation.

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