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논문 기본 정보

자료유형
학술저널
저자정보
Min Zhang (Capital Institute of Pediatrics) YiRan Wu (Capital Institute of Pediatrics) ZhaoXu Lu (Capital Institute of Pediatrics) MeiYan Song (Shanxi Medical University) XiaoLan Huang (Capital Institute of Pediatrics) LaLa Mi (Shanxi Medical University) Jian Yang (Capital Institute of Pediatrics) Xiaodai Cui (Capital Institute of Pediatrics)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제21권 제2호
발행연도
2023.5
수록면
240 - 251 (12page)
DOI
10.9758/cpn.2023.21.2.240

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초록· 키워드

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The effect of vitamin D supplementation on individuals with autism spectrum disorder (ASD) is inconclusive. We aimed to conduct a meta-analysis of the available randomized controlled trials (RCTs) to explore whether vitamin D supple mentation can improve core symptoms and coexisting conditions in children with ASD. Data were obtained by search ing the PubMed, Embase, Web of Science, CINAHL and Cochrane Library databases up to February 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a random-effects model, mean differences with 95% confidence intervals (CIs) were calculated through a meta-analysis. There were eight RCTs with 266 children with ASD in the present review, among which six RCTs were included in the meta-analysis. Children who received vitamin D supplementation showed a significant improvement in stereotypical behavior scores (pooled mean difference (MD): −1.39; 95% CI: −2.7, −0.07; p = 0.04) with low heterogeneity (I2 = 34%), and there was a trend toward decreased total scores on the Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS, p = 0.05); however, there were no other significant differences in the core symptoms of ASD and coexisting conditions between groups as measured by the Aberrant Behavior Checklist (ABC). Vitamin D supplementation appears to improve stereotypical behaviors but does not improve other core symptoms and coexisting conditions. Further randomized controlled trials with large sample sizes and individualized doses are needed.

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