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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 400 - 406 (7page)
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초록· 키워드
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Background: The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established. Objective: We investigated the association between vitamin D levels and HDM sensitization according to AD severity. Methods: In total, 80 patients (43 men and 37 women) with AD were included. We classified AD severity using Rajka and Langeland scores. Laboratory tests included serum 25-hydroxyvitamin D3, total immunoglobulin E (IgE), and specific IgE antibody titer against Dermatophagoides farinae and D. pteronyssinus. Results: There were no differences in vitamin D levels between the mild or moderate AD and severe AD groups. In the severe AD group, high HDM sensitization group had lower serum vitamin D levels compared to low HDM sensitization group with statistical significance. In addition, a significant negative correlation was found between vitamin D levels and HDM sensitization in the severe AD group. Conclusion: Our results demonstrate that low vitamin D levels may link to high HDM sensitization in patients with the severe AD.
Further elucidation of the role of vitamin D in HDM sensitization may hold profound implications for the prevention and treatment of AD.
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참고문헌 (24)
참고문헌 신청
Akan A / 2013 / Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations / Pediatr Dermatol 30 : 359 ~
Baek JH / 2014 / The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy / J Pediatr 165 : 849.e1 ~ 854.e1
Baeke F / 2010 / Vitamin D: modulator of the immune system / Curr Opin Pharmacol 10 : 482 ~ 496
Benson AA / 2012 / The role of vitamin D in the immunopathogenesis of allergic skin diseases / Allergy 67 : 296 ~ 301
Chiu YE / 2013 / Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity / J Am Acad Dermatol 69 : 40 ~ 46
Baek JH / 2014 / The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy / J Pediatr 165 : 849.e1 ~ 854.e1
Baeke F / 2010 / Vitamin D: modulator of the immune system / Curr Opin Pharmacol 10 : 482 ~ 496
Benson AA / 2012 / The role of vitamin D in the immunopathogenesis of allergic skin diseases / Allergy 67 : 296 ~ 301
Chiu YE / 2013 / Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity / J Am Acad Dermatol 69 : 40 ~ 46
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