지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,420 - 1,426 (7page)
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초록· 키워드
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Purpose: The clinical usefulness of subcutaneous allergen immunotherapy (SCIT) in the treatment of atopic dermatitis (AD) is still controversial. We analyzed the clinical efficacy of SCIT in patients with AD and the clinical characteristics of patients showing a favorable clinical response to the treatment.
Materials and Methods: Two hundred and fifty one patients with AD sensitized to house dust mite (HDM) were treated by SCIT using HDM extract. The clinical severity of AD was measured using the standardized clinical severity scoring system for AD (SCORAD)at baseline and 12 months. A favorable clinical response to SCIT was defined as a decrease in SCORAD value at 12 months greater than 50% compared to baseline value. Severe AD was defined as a baseline SCORAD value above 50.
Results: A favorable clinical response to SCIT was observed in 73.6% of patients. The proportion of patients showing a favorable clinicalresponse to SCIT was significantly higher in patients with severe AD (90.6%) than patients with mild to moderated AD (63.7%) (p<0.001). Patients with severe AD showing a favorable clinical response had a significantly shorter duration of AD (12.3±8.5 years; mean±SD) than patients with severe AD showing no significant clinical response (20.6±10.9 years) (p<0.05) at baseline.
Conclusion: SCIT could be a clinically useful therapeutic option for patients with severe AD sensitized to HDM. Early initiation of SCIT might provide a favorable clinical outcome in patients with severe AD sensitized to HDM.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Akdis CA / 2006 / Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report / J Allergy Clin Immunol 118:152~169
Bieber T / 2012 / Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine / Allergy 67:1475~1482
남동호 / 2015 / Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View / Annals of Dermatology 27(4):355~363
Beck LA / 2014 / Dupilumab treatment in adults with moderate-to-severe atopic dermatitis / N Engl J Med 371:130~139
남동호 / 2014 / Autologous Immunoglobulin Therapy in Patients With Severe Recalcitrant Atopic Dermatitis: A Preliminary Report / Allergy, Asthma & Immunology Research 6(1):89~94
Bieber T / 2012 / Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine / Allergy 67:1475~1482
남동호 / 2015 / Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View / Annals of Dermatology 27(4):355~363
Beck LA / 2014 / Dupilumab treatment in adults with moderate-to-severe atopic dermatitis / N Engl J Med 371:130~139
남동호 / 2014 / Autologous Immunoglobulin Therapy in Patients With Severe Recalcitrant Atopic Dermatitis: A Preliminary Report / Allergy, Asthma & Immunology Research 6(1):89~94
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