지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제3호
- 발행연도
- 2020.1
- 수록면
- 266 - 275 (10page)
이용수
초록· 키워드
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Purpose: The outcome predictors of Kasai portoenterostomy (KPE) for biliary atresia (BA) are controversial. This study aimed to identify possible short-term outcome predictors of KPE for BA in infants. Methods: This retrospective study included infants with BA who underwent KPE between January 2015 and December 2017 and were followed up for at least 6 months after surgery at the Pediatric Hepatology Unit, Cairo University Pediatric Hospital, Egypt. The short-term outcome was jaundice clearance within 6 months following surgery. All data were compared between the jaundice free group and those with persistent jaundice to identify the predictors of jaundice clearance. Results: The study included 75 infants. The mean age at the time of surgery was 82.43±22.77 days (range, 37–150 days), and 28 (37.3%) infants cleared their jaundice within 6 months postoperative. Age at surgery did not significantly affect the outcome (p=0.518). Infants with persistent jaundice had significantly higher pre-operative levels of aspartate aminotransferase (AST) than those who were jaundice free (p=0.041). Receiver operating characteristic curve analysis showed that preoperative AST ≤180 IU/L was predictive of a successful KPE, with sensitivity 74.5% and specificity 60.7%. Infants with bile plugs in liver biopsy had a 6-fold higher risk of persistent jaundice than those without bile plugs (95% confidence interval: 1.59–20.75, p=0.008). Conclusion: Jaundice clearance after KPE for BA can be predicted using preoperative AST and presence of bile plugs in liver biopsy.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Sokol RJ / 2007 / Screening and outcomes in biliary atresia : summary of a National Institutes of Health workshop / Hepatology 46:566~581
Shneider BL / 2016 / Total serum bilirubin within 3 months of hepatoportoenterostomy predicts short-term outcomes in biliary atresia / J Pediatr 170:211~217
Hartley JL / 2009 / Biliary atresia / Lancet 374:1704~1713
Shneider BL / 2006 / A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000 / J Pediatr 148:467~474
Davenport M / 2008 / Surgical outcome in biliary atresia : etiology affects the influence of age at surgery / Ann Surg 247:694~698
Shneider BL / 2016 / Total serum bilirubin within 3 months of hepatoportoenterostomy predicts short-term outcomes in biliary atresia / J Pediatr 170:211~217
Hartley JL / 2009 / Biliary atresia / Lancet 374:1704~1713
Shneider BL / 2006 / A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000 / J Pediatr 148:467~474
Davenport M / 2008 / Surgical outcome in biliary atresia : etiology affects the influence of age at surgery / Ann Surg 247:694~698
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