지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 810 - 819 (10page)
이용수
초록· 키워드
오류제보하기
For physiological or pathological understanding of bone disease caused by abnormal behavior of osteoclasts (OCs), functional studies of molecules that regulate the generation and action of OCs are required. In a microarray approach, we found the suppression of tumorigenicity 5 (ST5) gene is upregulated by receptor activator of nuclear factor-κB ligand (RANKL), the OC differentiation factor. Although the roles of ST5 in cancer and β-cells have been reported, the function of ST5 in bone cells has not yet been investigated. Knockdown of ST5 by siRNA reduced OC differentiation from primary precursors. Moreover, ST5 downregulation decreased expression of NFATc1, a key transcription factor for osteoclastogenesis. In contrast, overexpression of ST5 resulted in the opposite phenotype of ST5 knockdown. In immunocytochemistry experiments, the ST5 protein is colocalized with Src in RANKL-committed cells. In addition, ST5 enhanced activation of Src and Syk, a Src substrate, in response to RANKL. ST5 reduction caused a decrease in RANKL-evoked calcium oscillation and inhibited translocation of NFATc1 into the nucleus. Taken together, these findings provide the first evidence of ST5 involvement in positive regulation of osteoclastogenesis via Src/Syk/calcium signaling.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity
Molecules and Cells
2016 .04
-
The Inactivation of ERK1/2, p38 and NF-kB Is Involved in the Down-Regulation of Osteoclastogenesis and Function by A2B Adenosine Receptor Stimulation
Molecules and Cells
2017 .10
-
Roles of Steroid Receptor Coactivator-3 and TTF-1 in Lung Development and Lung Cancer
생명과학회지
2015 .12
-
상동나무 지상부의 항혈전 활성
생명과학회지
2020 .05
-
PARK2 Induces Osteoclastogenesis through Activation of the NF-κB Pathway
Molecules and Cells
2022 .10
-
대전지역의 요로감염 환자로부터 분리된 요로병인성 대장균ST131과 Non-ST131의 비교 분석
대한임상검사과학회지
2020 .01
-
유전적으로 암호화된 FRET 바이오센서를 통한 세포막 하위 도메인의 Src 활성 비교 분석
생명과학회지
2023 .02
-
Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation
Molecules and Cells
2017 .10
-
Comparative Genomics Approaches to Understanding Virulence and Antimicrobial Resistance of Salmonella Typhimurium ST1539 Isolated from a Poultry Slaughterhouse in Korea
Journal of Microbiology and Biotechnology
2019 .01
-
Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors
Molecules and Cells
2018 .06
-
Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
Molecules and Cells
2019 .01
-
Clonal and Virulence Distribution of Uropathogenic Escherichia coli Isolated from Children in Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .03
-
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
Molecules and Cells
2015 .01
-
갈색거저리 유충 에탄올 추출물이 RANKL에 의해 유도되는 파골세포 분화에 미치는 영향
생명과학회지
2020 .11
-
Antimicrobial agents, outer membrane assembly machine, lipoprotein, lipopolysaccharide, outer membrane β-barrel protein, phospholipid
Journal of Microbiology and Biotechnology
2019 .01
-
RANKL 유도된 파골세포 분화에 대한 풀무치 에탄올 추출물의 분화 억제 효과
생명과학회지
2019 .10
-
2013~2016년 제주 PM2.5 화학조성 변화 및 고농도 발생 특성
한국대기환경학회지(국문)
2020 .06
-
3.1 운동 역사적 의미의 제고를 위한 삼일대로 재개발 계획 - 서울특별시 종로구 인사동 삼일대로 재개발계획안 -
한국주거학회 학술대회논문집
2019 .11
-
동강 지류 기화천의 저서성 대형무척추동물 군집특성
생태와 환경
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0