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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 884 - 892 (9page)
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Piperlongumine (PL), a natural alkaloid compound isolated from long pepper (Piper longum), can selectively kill cancer cells, but not normal cells, by accumulation of reactive oxygen species (ROS). The objective of this study was to investigate functional roles of expression of SETDB1 and FosB during PL treatment in MCF7 breast cancer cells. PL downregulates SETDB1 expression, and decreased SETDB1 expression enhanced caspase 9 dependent-PARP cleavage during PL-induced cell death. PL treatment generated ROS. ROS inhibitor NAC (N-acetyl cysteine) recovered SETDB1 expression decreased by PL. Decreased SETDB1 expression induced transcriptional activity of FosB during PL treatment. PARP cleavage and positive annexin V level were increased during PL treatment with FosB overexpression whereas PARP cleavage and positive annexin V level were decreased during PL treatment with siFosB transfection, implying that FosB might be a pro-apoptotic protein for induction of cell death in PL-treated MCF7 breast cancer cells. PL induced cell death in A549 lung cancer cells, but molecular changes involved in the induction of these cell deaths might be different. These results suggest that SETDB1 mediated FosB expression may induce cell death in PL-treated MCF7 breast cancer cells.
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참고문헌 (38)
참고문헌 신청
Al Emran, A. / 2018 / Distinct histone modifications denote early stress-induced drug tolerance in cancer / Oncotarget 9:8206~8222
Barrett, C. S. / 2017 / TGF-beta effects on prostate cancer cell migration and invasion require FosB / Prostate 77:72~81
Dhillon, A. S. / 2007 / MAP kinase signalling pathways in cancer / Oncogene 26:3279~3290
Du, D. / 2018 / Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelialmesenchymal transition / EMBO Rep 19:135~155
Gajewski, P. A. / 2016 / Differential expression of FosB proteins and potential target genes in select brain regions of addiction and depression patients / PLoS One 11:e0160355
Barrett, C. S. / 2017 / TGF-beta effects on prostate cancer cell migration and invasion require FosB / Prostate 77:72~81
Dhillon, A. S. / 2007 / MAP kinase signalling pathways in cancer / Oncogene 26:3279~3290
Du, D. / 2018 / Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelialmesenchymal transition / EMBO Rep 19:135~155
Gajewski, P. A. / 2016 / Differential expression of FosB proteins and potential target genes in select brain regions of addiction and depression patients / PLoS One 11:e0160355
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