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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 362 - 372 (11page)
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Setdb1, an H3-K9 specific histone methyltransferase, is associated with transcriptional silencing of euchromatic genes through chromatin modification. Functions of Setdb1 during development have been extensively studied in embryonic and mesenchymal stem cells as well as neurogenic progenitor cells. But the role of Sedtdb1 in myogenic differentiation remains unknown. In this study, we report that Setdb1 is required for myogenic potential of C2C12 myoblast cells through maintaining the expressions of MyoD and muscle-specific genes. We find that reduced Setdb1 expression in C2C12 myoblast cells severely delayed differentiation of C2C12 myoblast cells, whereas exogenous Setdb1 expression had little effect on. Gene expression profiling analysis using oligonucleotide microarray and RNA-Seq technologies demonstrated that depletion of Setdb1 results in downregulation of MyoD as well as the components of muscle fiber in proliferating C2C12 cells. In addition, exogenous expression of MyoD reversed transcriptional repression of MyoD promoter-driven luciferase reporter by Setdb1 shRNA and rescued myogenic differentiation of C2C12 myoblast cells depleted of endogenous Setdb1. Taken together, these results provide new insights into how levels of key myogenic regulators are maintained prior to induction of differentiation.
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참고문헌 (45)
참고문헌 신청
Bilodeau, S. / 2009 / SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state / Genes Dev 23:2484~2489
Blais, A. / 2005 / An initial blueprint for myogenic differentiation / Genes Dev 19:553~569
Blum, R. / 2013 / The role of MyoD1 and histone modifications in the activation of muscle enhancers / Epigenetics 8:778~784
Cao, Y. / 2006 / Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters / EMBO J 25:502~511
Caretti, G. / 2004 / The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation / Genes Dev 18:2627~2638
Blais, A. / 2005 / An initial blueprint for myogenic differentiation / Genes Dev 19:553~569
Blum, R. / 2013 / The role of MyoD1 and histone modifications in the activation of muscle enhancers / Epigenetics 8:778~784
Cao, Y. / 2006 / Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters / EMBO J 25:502~511
Caretti, G. / 2004 / The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation / Genes Dev 18:2627~2638
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