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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 667 - 676 (10page)
- DOI
- 10.14348/molcells.2017.0116
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초록· 키워드
오류제보하기
Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that regulate muscle differentiation will be useful in the treatment and prevention of these conditions. Protein lysine acetylation and methylation are major post-translational modification mecha-nisms that regulate key cellular processes. In this study, to elucidate the relationship between myogenic differentiation and protein lysine acetylation/methylation, we performed a PCR array of enzymes related to protein lysine acetylation/methylation during C2C12 myoblast differentiation. Our results indicated that the expression pattern of HDAC11 was substantially increased during myoblast differentiation. Fur-thermore, ectopic expression of HDAC11 completely inhibited myoblast differentiation, concomitant with reduced expression of key myogenic transcription factors. However, the catalytically inactive mutant of HDAC11 (H142/143A) did not impede myoblast differentiation. In addition, wild-type HDAC11, but not the inactive HDAC11 mutant, suppressed MyoD-induced promoter activities of MEF2C and MYOG (Myogenin), and reduced histone acetylation near the E-boxes, the MyoD binding site, of the MEF2C and MYOG promoters. Collectively, our results indicate that HDAC11 would suppress myoblast differentiation via regulation of MyoD-dependent transcription. These findings suggest that HDAC11 is a novel critical target for controlling myoblast differentiation.
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등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Ait-Si-Ali, S. / 2004 / A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells / EMBO J 23:605~615
Berendse, M. / 2003 / Myoblast structure affects subsequent skeletal myotube morphology and sarcomere assembly / Exp. Cell Res 291:435~450
Bergstrom, D. A. / 2002 / Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression / Mol. Cell 9:587~600
Braun, T. / 1989 / A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2fibroblasts / EMBO J 8:701~709
Braun, T. / 1990 / Myf-6, a new member of the human gene family of myogenic determination factors : evidence for a gene cluster on chromosome 12 / EMBO J 9:821~831
Berendse, M. / 2003 / Myoblast structure affects subsequent skeletal myotube morphology and sarcomere assembly / Exp. Cell Res 291:435~450
Bergstrom, D. A. / 2002 / Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression / Mol. Cell 9:587~600
Braun, T. / 1989 / A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2fibroblasts / EMBO J 8:701~709
Braun, T. / 1990 / Myf-6, a new member of the human gene family of myogenic determination factors : evidence for a gene cluster on chromosome 12 / EMBO J 9:821~831
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