지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 200 - 209 (10page)
이용수
초록· 키워드
오류제보하기
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been used as promising tools for regenerative medicine, disease modeling, and drug screening. Traditional and common strategies for pluripotent stem cell (PSC) differentiation toward disease-relevant cell types depend on sequential treatment of signaling molecules identified based on knowledge of developmental biology. However, these strategies suffer from low purity, inefficiency, and timeconsuming culture conditions. A growing body of recent research has shown efficient cell fate reprogramming by forced expression of single or multiple transcription factors. Here, we review transcription factor-directed differentiation methods of PSCs toward neural, muscle, liver, and pancreatic endocrine cells. Potential applications and limitations are also discussed in order to establish future directions of this technique for therapeutic purposes.
목차
등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Akiyama, T. / 2016 / Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells / Development 143:3674~3685
Albini, S. / 2013 / Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres / Cell Rep 3:661~670
Bai, F. / 2015 / Directed differentiation of embryonic stem cells into cardiomyocytes by bacterial injection of defined transcription factors / Sci. Rep 5:15014
Bernardo, A. S. / 2009 / Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic β-cells / Stem Cells 27:341~351
Blyszczuk, P. / 2003 / Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulinproducing cells / Proc. Natl. Acad. Sci. USA 100:998~1003
Albini, S. / 2013 / Epigenetic reprogramming of human embryonic stem cells into skeletal muscle cells and generation of contractile myospheres / Cell Rep 3:661~670
Bai, F. / 2015 / Directed differentiation of embryonic stem cells into cardiomyocytes by bacterial injection of defined transcription factors / Sci. Rep 5:15014
Bernardo, A. S. / 2009 / Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic β-cells / Stem Cells 27:341~351
Blyszczuk, P. / 2003 / Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulinproducing cells / Proc. Natl. Acad. Sci. USA 100:998~1003
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
iPSC-Derived Natural Killer Cells for Cancer Immunotherapy
Molecules and Cells
2021 .08
-
Homogeneity of XEN Cells Is Critical for Generation of Chemically Induced Pluripotent Stem Cells
Molecules and Cells
2023 .04
-
Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells without Microenvironment of Feeder Cells
Molecules and Cells
2018 .07
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
-
Characterizing Organelles in Live Stem Cells Using Label-Free Optical Diffraction Tomography
Molecules and Cells
2021 .11
-
NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells
Molecules and Cells
2020 .01
-
MicroRNA-126은 난소 종양세포의 줄기세포 전사인자 (Sox2와 Lin28) 발현을 조절한다
대한임상검사과학회지
2015 .01
-
Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations
Molecules and Cells
2018 .07
-
Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets
Journal of Microbiology and Biotechnology
2022 .12
-
Role of non-thermal atmospheric pressure bio-compatible plasma on human stem cells
한국진공학회 학술발표회초록집
2017 .02
-
Differentiation of mesenchymal stem cells on nanopillar/pit array structures
한국진공학회 학술발표회초록집
2017 .02
-
The Role of Stress Granules in the Neuronal Differentiation of Stem Cells
Molecules and Cells
2020 .01
-
Diesel particulate matter 2.5 induces fibrotic changes during human pluripotent stem cell-derived alveolar organoid development
한국분석과학회 학술대회
2020 .11
-
Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells
Molecules and Cells
2018 .02
-
Inhibition of MicroRNA-221 and 222 Enhances Hematopoietic Differentiation from Human Pluripotent Stem Cells via c-KIT Upregulation
Molecules and Cells
2018 .01
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
ROCK 억제제를 통한 사람 치유두 조직 유래 단일 사람 유도만능줄기세포의 생존성 향상
생명과학회지
2019 .08
-
The Kleisin Subunits of Cohesin are Involved in the Fate Determination of Embryonic Stem Cells
Molecules and Cells
2022 .11
-
Applications, challenges, and prospects of induced pluripotent stem cells for vascular disease
Molecules and Cells
2024 .01
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0