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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.7
- 수록면
- 613 - 621 (9page)
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초록· 키워드
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The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, cardiac drug toxicology screening, and human cardiac disease modeling. However, their applicability is significantly limited by immature phenotypes. It has been well known that currently available CMs derived from hPSCs (hPSC-CMs) represent immature embryonic or fetal stage CMs and are functionally and structurally different from mature human CMs. To overcome this critical issue, several new approaches aiming to generate more mature hPSC-CMs have been developed. This re-view describes recent approaches to generate more mature hPSC-CMs including their scientific prin-ciples, advantages, and limitations.
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등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Amin, A.S. / 2010 / Cardiac ion channels in health and disease / Heart Rhythm 7:117~126
Camci-Unal, G. / 2014 / Hydrogels for cardiac tissue engineering / NPG Asia Mater 6:e99
Chattergoon, N.N. / 2012 / Thyroid hormone drives fetal cardiomyocyte maturation / FASEB J 26:397~408
Davis, R.P. / 2012 / Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease / Circulation 125:3079~3091
DeForest, C.A. / 2012 / Advances in bioactive hydrogels to probe and direct cell fate / Annu. Rev. Chem. Biomol. Eng. 3:421~444
Camci-Unal, G. / 2014 / Hydrogels for cardiac tissue engineering / NPG Asia Mater 6:e99
Chattergoon, N.N. / 2012 / Thyroid hormone drives fetal cardiomyocyte maturation / FASEB J 26:397~408
Davis, R.P. / 2012 / Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease / Circulation 125:3079~3091
DeForest, C.A. / 2012 / Advances in bioactive hydrogels to probe and direct cell fate / Annu. Rev. Chem. Biomol. Eng. 3:421~444
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