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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 905 - 912 (8page)
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Myocardial infarction (MI) is a major cause of death worldwide. The treatment of MI has improved during the last decade; however, the loss of myocytes remains a problem because the cells cannot be renewed. Cardiac stem cells were recently discovered and were thought to represent a promising treatment for MI. However, the efficiency of cardiac stem cell differentiation into myocyte is not sufficient. Hepatocyte growth factor (HGF) is related to the differentiation and proliferation of cardiac stem cells. p27kip1 is a potent cell cycle inhibitor in most organs, especially the heart. In this study, we investigated the relationship among p27, HGF and cardiac stem cells in post-MI cardiac repair. We found that p27 haploinsufficient mice exhibited preserved cardiac function and improved cardiomyocyte renewal compared with wild-type mice. In addition, p27 haploinsufficiency may not increase cardiac stem cell proliferation but could improve their differentiation by increasing mammalian target of rapamycin expression.
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참고문헌 (37)
참고문헌 신청
Bearzi C / 2007 / Human cardiac stem cell / Proc Natl Acad Sci USA 104:14068~14073
Beltrami AP / 2003 / Adult cardiac stem cells are multipotent and support myocardial regeneration / Cell 114:763~776
Birchmeier C / 2000 / Genes that control the development of migrating muscle precursor cells / Curr Opin Cell Biol 12:725~730
Canicio J / 1998 / p70 S6 kinase activation is not required for insulin-like growth factor-induced differentiation of rat, mouse, or human skeletal muscle cells / Endocrinology 139:5042~5049
Chandrasekher G / 2014 / Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth / Mol Vis 20:24~37
Beltrami AP / 2003 / Adult cardiac stem cells are multipotent and support myocardial regeneration / Cell 114:763~776
Birchmeier C / 2000 / Genes that control the development of migrating muscle precursor cells / Curr Opin Cell Biol 12:725~730
Canicio J / 1998 / p70 S6 kinase activation is not required for insulin-like growth factor-induced differentiation of rat, mouse, or human skeletal muscle cells / Endocrinology 139:5042~5049
Chandrasekher G / 2014 / Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth / Mol Vis 20:24~37
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