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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 906 - 918 (13page)
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초록· 키워드
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MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.
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참고문헌 (49)
참고문헌 신청
Ailawadi, S. / 2015 / Pathologic function and therapeutic potential of exosomes in cardiovascular disease / Biochim. Biophys. Acta 1852:1~11
Alvarez-Erviti, L. / 2011 / Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes / Nat. Biotechnol 29:341~345
An Haack, I. / 2015 / The role of regulatory CD4 T cells in maintaining tolerance in a mouse model of autoimmune hepatitis / PLoS One 10:e0143715
Bang, C. / 2014 / Cardiac fibroblastderived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy / J. Clin. Invest 124:2136~2146
Bettelli, E. / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441:235~238
Alvarez-Erviti, L. / 2011 / Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes / Nat. Biotechnol 29:341~345
An Haack, I. / 2015 / The role of regulatory CD4 T cells in maintaining tolerance in a mouse model of autoimmune hepatitis / PLoS One 10:e0143715
Bang, C. / 2014 / Cardiac fibroblastderived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy / J. Clin. Invest 124:2136~2146
Bettelli, E. / 2006 / Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells / Nature 441:235~238
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