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자료유형
학술저널
저자정보
Iqbal Jalaludin (Chungnam National University) David M. Lubman (University of Michigan Medical Center) Jeongkwon Kim (Chungnam National University)
저널정보
한국질량분석학회 Mass Spectrometry Letters Mass Spectrometry Letters Vol.12 No.3
발행연도
2021.9
수록면
93 - 105 (13page)

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초록· 키워드

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Exosomes have gained the attention of the scientific community because of their role in facilitating intercellular communication, which is critical in disease monitoring and drug delivery research. Exosome research has grown significantly in recent decades, with a focus on the development of various technologies for isolating and characterizing exosomes. Among these efforts is the use of matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), which offers high-throughput direct analysis while also being cost and time effective. MALDI is used less frequently in exosome research than electrospray ionization due to the diverse population of extracellular vesicles and the impurity of isolated products, both of which necessitate chromatographic separation prior to MS analysis. However, MALDI-MS is a more appropriate instrument for the analytical approach to patient therapy, given it allows for fast and label-free analysis. There is a huge drive to explore MALDI-MS in exosome research because the technology holds great potential, most notably in biomarker discovery. With methods such as fingerprint analysis, OMICs profiling, and statistical analysis, the search for biomarkers could be much more efficient. In this review, we highlight the potential of MALDI-MS as a tool for investigating exosomes and some of the possible strategies that can be implemented based on prior research.

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Abstract
I. Introduction
II. MALDI-MS
III. Extracellular vesicles
IV. MALDI-MS strategies in exosome research
V. Conclusion
References

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