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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제3호
- 발행연도
- 2020.1
- 수록면
- 427 - 438 (12page)
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Middle East respiratory syndrome coronavirus (MERS-CoV) infects the lower respiratory airway of humans, leading to severe acute respiratory failure. Unlike human dipeptidyl peptidase 4 (hDPP4), a receptor for MERS-CoV, mouse DPP4 (mDPP4) failed to support MERS-CoV infection. Consequently, diverse transgenic mouse models expressing hDPP4 have been developed using diverse methods, although some models show no mortality and/or only transient and mild-to-moderate clinical signs following MERS-CoV infection. Additionally, overexpressed hDPP4 is associated with neurological complications and breeding difficulties in some transgenic mice, resulting in impeding further studies. Here, we generated stable hDPP4-transgenic mice that were sufficiently susceptible to MERS-CoV infection. The transgenic mice showed weight loss, decreased pulmonary function, and increased mortality with minimal perturbation of overexpressed hDPP4 after MERS-CoV infection. In addition, we observed histopathological signs indicative of progressive pulmonary fibrosis, including thickened alveolar septa, infiltration of inflammatory monocytes, and macrophage polarization as well as elevated expression of profibrotic molecules and acute inflammatory response in the lung of MERS-CoV-infected hDPP4-transgenic mice. Collectively, we suggest that this hDPP4-transgenic mouse is useful in understanding the pathogenesis of MERS-CoV infection and for antiviral research and vaccine development against the virus.
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참고문헌 (45)
참고문헌 신청
WHO MERS-CoV Research Group / 2013 / State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans / PLoS Curr 5
이정윤 / 2019 / Generation of Full-Length Infectious cDNA Clones of Middle East Respiratory Syndrome Coronavirus / Journal of Microbiology and Biotechnology 29(6):999~1007
Raj VS / 2013 / Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC / Nature 495:51~254
van Doremalen N / 2014 / Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 / J. Virol 88:220~9232
Boonacker E / 2003 / The multifunctional or moonlighting protein CD26/DPPIV / Eur. J. Cell Biol 82:53~73
이정윤 / 2019 / Generation of Full-Length Infectious cDNA Clones of Middle East Respiratory Syndrome Coronavirus / Journal of Microbiology and Biotechnology 29(6):999~1007
Raj VS / 2013 / Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC / Nature 495:51~254
van Doremalen N / 2014 / Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 / J. Virol 88:220~9232
Boonacker E / 2003 / The multifunctional or moonlighting protein CD26/DPPIV / Eur. J. Cell Biol 82:53~73
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