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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 395 - 398 (4page)
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초록· 키워드
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Background: Obesity causes several changes in the body and is associated with both inflammation and oxidative stress. However, the relationship between abdominal obesity, diacron-reactive oxygen metabolites (d-ROMs), and biological antioxidant potential (BAP) levels in Korean adults has not yet been proved. The aim of this study was to evaluate the association between d-ROMs, BAP levels, and abdominal obesity in the Korean adult population using clinical data. Methods: A total of 2,367 individuals, aged 18–86 years, were identified from health check-up examination records at a university hospital, between January 2015 and August 2016. Clinical and biochemical parameters, including waist circumference, lipid profile, alcohol drinking status, and smoking status, were investigated. Oxidative stress levels, viz., d-ROM concentration and antioxidant capacity, viz., BAP, were measured. Results: Subjects with abdominal obesity presented significantly higher levels of d-ROMs compared to those with a normal waist circumference (P<0.001). After adjusting for age, sex, alcohol drinking status; smoking status; and triglyceride, low-density lipoprotein levels were found to have a significant positive correlation with abdominal obesity (P<0.001). BAP did not significantly correlate with abdominal obesity. Conclusion: We observed a positive association between abdominal obesity and d-ROM concentration. This result indicates that abdominal obesity can increase oxidative stress and may affect the pathways involved in obesity, such as the inflammatory pathway. Such correlation analyses were helpful in revealing the causes, as well as methods to reduce, oxidative stress.
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참고문헌 (25)
참고문헌 신청
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Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation / Diabet Med 15:539~553
Bondia-Pons I / 2012 / Oxidative stress and inflammation interactions in human obesity / J Physiol Biochem 68:701~711
Maury E / 2010 / Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome / Mol Cell Endocrinol 314:1~16
Galic S / 2010 / Adipose tissue as an endocrine organ / Mol Cell Endocrinol 316:129~139
Alberti KG / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation / Diabet Med 15:539~553
Bondia-Pons I / 2012 / Oxidative stress and inflammation interactions in human obesity / J Physiol Biochem 68:701~711
Maury E / 2010 / Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome / Mol Cell Endocrinol 314:1~16
Galic S / 2010 / Adipose tissue as an endocrine organ / Mol Cell Endocrinol 316:129~139
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