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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 99 - 107 (9page)
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초록· 키워드
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Objectives: We accessed the various clinico-histopathological factors, and their association with occult metastasis (OM) in oral tongue squamous cell carcinoma (OTSCC). Materials and Methods: One hundred-nine patients with OTSCC were divided into the elective neck dissection (END) group and the watchful waiting (WW) group. Age, sex, T-stage, depth of invasion and differentiation were evaluated to determine the correlation between clinico-histopathological factors and OM. For immunohistochemical analysis, paraffin-embedded blocks of 41 OTSCC specimens were examined with antibodies (VEGF-c, c-Met, and ROR1). Results: The group with tumor thickness of oral tongue cancer ≥3 mm had higher incidence of OM than those with a thickness of <3 mm. The depth of invasion was statistically correlated with OM (P=0.022). Immunohistochemical analysis showed that high expression of VEGF-c (P=0.043), c-Met (P=0.009), and ROR-1 (P=0.003) were statistically correlated with OM. Conclusion: The analysis of these clinico-histopathological and immunohistochemical factors can help to determine neck dissection in clinically negative (cN0) patients.
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참고문헌 (47)
참고문헌 신청
Ho CM / 1992 / Occult lymph node metastasis in small oral tongue cancers / Head Neck 14:359~363
Grandi C / 1985 / Prognostic significance of lymphatic spread in head and neck carcinomas : therapeutic implications / Head Neck Surg 8:67~73
Snow GB / 1982 / Prognostic factors of neck node metastasis / Clin Otolaryngol Allied Sci 7:185~192
Whitehurst JO / 1977 / Surgical treatment of squamous cell carcinoma of the oral tongue : factors influencing survival / Arch Otolaryngol 103:212~215
van den Brekel MW / 1990 / Cervical lymph node metastasis : assessment of radiologic criteria / Radiology 177:379~384
Grandi C / 1985 / Prognostic significance of lymphatic spread in head and neck carcinomas : therapeutic implications / Head Neck Surg 8:67~73
Snow GB / 1982 / Prognostic factors of neck node metastasis / Clin Otolaryngol Allied Sci 7:185~192
Whitehurst JO / 1977 / Surgical treatment of squamous cell carcinoma of the oral tongue : factors influencing survival / Arch Otolaryngol 103:212~215
van den Brekel MW / 1990 / Cervical lymph node metastasis : assessment of radiologic criteria / Radiology 177:379~384
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