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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 411 - 419 (9page)
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초록· 키워드
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ObjectiveBRCA mutational status is important in the management of ovarian cancer, but there is a lack of evidence supportinggenetic testing in Asian populations. This study was performed to investigate the prevalence and prognostic outcomesof BRCA1/2 mutation and variant of unknown significance (VUS) in Korean patients diagnosed with epithelial ovariancancer (EOC). MethodsAmong patients newly diagnosed with EOC between January 2007 and January 2017, those tested for germlineBRCA1/2 mutation were studied, regardless of family history. Overall survival (OS) and progression-free survival (PFS)were compared between the patients with and without BRCA1/2 mutation and VUS. ResultsA total of 313 patients underwent BRCA testing: 88 patients had a BRCA1/2 mutation and 48 patients had a BRCA1/2VUS (28.1% and 15.3%, respectively). There were no significant associations between BRCA1/2 mutation, BRCA1/2wild-type, or BRCA1/2 VUS with age at diagnosis, histologic distribution, or residual disease status after primarycytoreductive surgery. BRCA1 mutation, including BRCA1 VUS, showed no difference in PFS or OS compared to BRCA1wild-type. In contrast, BRCA2 mutation showed longer PFS than that of BRCA2 wild-type (P=0.04) or BRCA2 VUS(P=0.02). BRCA2 mutation, including BRCA2 VUS, did not show any difference in OS compared to BRCA2 wild-type. ConclusionBRCA mutation and BRCA VUS had similar clinical characteristics and survival outcomes, except that BRCA2 mutationshowed better PFS. The results of this study will help to understand the prognostic significance of BRCA mutation andVUS in Korean patients.
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참고문헌 (26)
참고문헌 신청
Banerjee S / 2013 / New strategies in the treatment of ovarian cancer : current clinical perspectives and future potential / Clin Cancer Res 19:961~968
George SH / 2014 / BRCA and early events in the development of serous ovarian cancer / Front Oncol 4:5
Hyman DM / 2012 / Improved survival for BRCA2-associated serous ovarian cancer compared with both BRCAnegative and BRCA1-associated serous ovarian cancer / Cancer 118:3703~3709
Yang D / 2011 / Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer / JAMA 306:1557~1565
Lim MC / 2009 / BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients / J Cancer Res Clin Oncol 135:1593~1599
George SH / 2014 / BRCA and early events in the development of serous ovarian cancer / Front Oncol 4:5
Hyman DM / 2012 / Improved survival for BRCA2-associated serous ovarian cancer compared with both BRCAnegative and BRCA1-associated serous ovarian cancer / Cancer 118:3703~3709
Yang D / 2011 / Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer / JAMA 306:1557~1565
Lim MC / 2009 / BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients / J Cancer Res Clin Oncol 135:1593~1599
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