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ObjectiveThe umbilicus is a single, painful incisional site on the abdomen during trans-umbilical single-port access laparoscopicsurgery. Previously, we found that periumbilical lidocaine could reduce postoperative pain. This study aimed tocompare the efficacy of bupivacaine and lidocaine in reducing pain. MethodsWe performed a retrospective analysis in a study group (Bupivacaine group, 100 patients who received periumbilicalinfiltration of bupivacaine before their incisional site repair completion) and control group (Lidocaine group, 100patients who received lidocaine at their incisional site repair completion). We compared postoperative pain based onthe numerical rating scale (NRS) between propensity score-matched Bupivacaine-treated (n=50) and Lidocaine-treated(n=50) patients. ResultsThe postoperative pain scores based on the NRS were not significantly different between the 2 groups until 12 hourspost-operation. However, 24 hours post-operation, the Bupivacaine group showed significantly lower pain than theLidocaine group (24 hours, 1.76±1.07 vs. 2.53±1.11 NRS, P<0.001; 48 hours, 0.84±0.85 vs. 2.16±0.85 NRS, P<0.001). ConclusionPeriumbilical infiltration of bupivacaine has a longer acting efficacy on reducing postoperative surgical pain than thatof lidocaine.

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