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논문 기본 정보

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학술저널
저자정보
Ping, Bushara (Faculty of Odonto-Stomatology, University of Health Sciences) Kiattavorncharoen, Sirichai (Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Mahidol University) Durward, Callum (Department of Dentistry, University of Puthisastra) Im, Puthavy (Dean of Faculty of Odonto-Stomatology, University of Health Sciences) Saengsirinavin, Chavengkiat (Research office, Faculty of Dentistry, Mahidol University) Wongsirichat, Natthamet (Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Mahidol University)
저널정보
대한치과마취과학회 Journal of dental anesthesia and pain medicine Journal of dental anesthesia and pain medicine 제15권 제3호
발행연도
2015.1
수록면
121 - 128 (8page)

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Background: The authors studied the hemodynamic effect influent by using the novel high concentration of lidocaine HCl for surgical removal impacted lower third molar. The objective of this study was to evaluate the hemodynamic change when using different concentrations of lidocaine in impacted lower third molar surgery. Methods: Split mouth single blind study comprising 31 healthy patients with a mean age of 23 years (range 19-33 years). Subjects had symmetrically impacted lower third molars as observed on panoramic radiograph. Each participant required 2 surgical interventions by the same surgeon with a 3-week washout period washout period. The participants were alternately assigned one of two types of local anesthetic (left or right) for the first surgery, then the other type of anesthetic for the second surgery. One solution was 4% lidocaine with 1:100,000 epinephrine and the other was 2% lidocaine with 1:100,000 epinephrine. A standard IANB with 1.8 ml volume was used. Any requirement for additional anesthetic and patient pain intra-operation was recorded. Post-operatively, patient was instructed to fill in the patient report form for any adverse effect and local anesthetic preference in terms of intra-operative pain. This form was collected at the seven day follow up appointment. Results: In the 4% lidocaine group, the heart rate increased during the first minute post-injection (P < 0.05). However, there was no significant change in arterial blood pressure during the operation. In the 2% lidocaine group, there was a significant increase in arterial blood pressure and heart rate in the first minute following injection for every procedure. When the hemodynamic changes in each group were compared, the 4% lidocaine group had significantly lower arterial blood pressure compared to the 2% lidocaine group following injection. Post-operatively, no adverse effects were observed by the operator and patient in either local anesthetic group. Patients reported less pain intra-operation in the 4% lidocaine group compared with the 2% lidocaine group (P < .05). Conclusions: Our results suggest that a 4% concentration of lidocaine HCl with 1:100,000 epinephrine has better clinical efficacy than 2% lidocaine HCl with 1:100,000 epinephrine when used for surgical extraction of lower third molars. Neither drug had any clinical adverse effects.
#Adverse effects #Concentration of lidocaine hydrochloride #Efficacy local anesthetic #Hemodynamic changes #Inferior alveolar nerve block #IANB) #Lower impacted third molar

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참고문헌 (25)

참고문헌 신청
McLure HA / 2005 / Review of local anaesthetic agents / Minerva Anestesiol 71:59~74 google schola SF M / 2014 / Handbook of Local Anesthesia google schola Ping B / 2014 / Effect of high concentration lidocaine for mandibular teeth anesthesia: Review of literature / M Dent J 34:364~372 google schola Brand HS / 1996 / Cardiovascular responses induced by dental treatment / Eur J Oral Sci 104:245~252 google schola Sapira JD / 1971 / Human epinephrine secretion. Direct measurement of the secretion of epinephrine from the human adrenal medulla / J Clin Endocrinol Metab 33:436~447 google schola

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